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Review Articles

 

50. Forbidden Chemistries – Paths to a Sustainable Future Engaging Continuous Processing
B. Gutmann, C. O. Kappe
J. Flow. Chem. 2017, 7, in press.

49. Why Flow Means Green – Evaluating the Merits of Continuous Processing in the Context of Sustainability.
D. Dallinger, C. O. Kappe
Curr. Opin. Green Sust. Chem. 2017, 7, 6-12.

48. Halogenation of Organic Compounds using Continuous Flow and Microreactor Technology
D. Cantillo, C. O. Kappe
React. Chem. Eng. 2017, 2, 7-19.

47. Enabling Technologies for Diazomethane Generation and Reaction
D. Dallinger, C. O. Kappe,
Aldrichim. Acta 2016, 49, 57-66.

46. The Use of Molecular Oxygen in Pharmaceutical Manufacturing - Is Flow the Way to Go?
C. Hone, D. Roberge, C. O. Kappe,
ChemSusChem 2016, 10, 32-41.

45. Taming "Forbidden" Olefin Reductions Using Hydrazine and Oxygen by Continuous Flow Technology
B. Pieber, C. O. Kappe,
Chim. Oggi/Chem. Today 2016, 34(3), 38-42.

44. Aerobic Oxidations in Continuous Flow
B. Pieber, C. O. Kappe,
Top. Organometal. Chem. 2016, 57, 97-137.

43. Homogeneous Vs Immobilized Palladium Catalysts for Continuous Flow Cross-Coupling Chemistry
D. Cantillo, C. O. Kappe,
Chim. Oggi/Chem. Today 2015, 33(S), 6-10.

42. Forbidden Chemistries Go Flow in API Synthesis
B. Gutmann, C. O. Kappe,
Chim. Oggi/Chem. Today 2015, 33(3), 14-18.

41. Use of Continuous Flow Technology to Harness Hazardous Chemistries and Process Conditions – A Tool for the Manufacturing of Active Pharmaceutical Ingredients
B. Gutmann, D. Cantillo, C. O. Kappe,
Angew. Chem. Int. Ed. 2015, 54, 6688-6729.

40. Immobilized Transition Metals as Catalysts for Cross-Couplings in Continuous Flow - A Critical Assessment of the Reaction Mechanism and Metal Leaching.
D. Cantillo, C. O. Kappe
ChemCatChem 2014, 6, 3286-3305.

39. Anthropogenic Reaction Parameters – The Missing Link between Chemical Intuition and the Available Chemical Space.
G. M. Keserű, T. Soós, C.O. Kappe
Chem. Sov. Rev. 2014, 43, 5387-5399.

38. Reply to the Comments on Microwave Effects in Organic Synthesis
C. O. Kappe,
Angew. Chem. Int. Ed. 2013, 52, 7924-7928.

37. How to Measure Reaction Temperature in Microwave-heated Transformations.
C.O. Kappe
Chem. Sov. Rev. 2013, 42, 4977-4990.

36. Unraveling the Mysteries of Microwave Chemistry Using Silicon Carbide Reactor Technology.
C.O. Kappe
Acc. Chem. Res. 2013, 46, 1579-1585.

35. Microwave Effects in Organic Synthesis – Myth or Reality?
C. O. Kappe, B. Pieber, D. Dallinger
Angew. Chem. Int. Ed. 2013, 52, 1088-1094.

34. Parallel Microwave Chemistry in Silicon Carbide Microtiter Platforms – A Review
C. O. Kappe, M. Damm
Mol. Diversity 2012, 16, 5-25.

33. Microwave-Assisted Synthesis of Colloidal Inorganic Nanocrystals.
M. Baghbanzadeh, L. Carbone, P. D. Cozzoli, C. O. Kappe
Angew. Chem. Int. Ed. 2011, 50, 11312-11359.

32. The Microwave-to-Flow Paradigm: Translating High-Temperature Batch Microwave Chemistry to Scalable Continuous Flow Processes.
T. N. Glasnov, C. O. Kappe
Chem. Eur. J. 2011, 17, 11956-11968.

31. A Critical Assessment of the Greenness and Energy Efficiency of Microwave-assisted Organic Synthesis.
J. D. Moseley, C. O. Kappe
Green Chem. 2011, 13, 794-806.

30. Heterogeneous Catalytic Hydrogenation Reactions Using Continuous Flow Reactors.
M. Irfan, T. N. Glasnov, C. O. Kappe
ChemSusChem 2011, 4, 300-316.

29. Continuous Flow Synthesis of Heterocycles.
T. N. Glasnov, C. O. Kappe
J. Heterocycl. Chem. 2011, 48, 11-29.

28. Microwave-assisted Derivatization Procedures for Gas Chromatography/Mass Spectrometry Analysis.S. L. Söderholm, M. Damm, C. O. Kappe
Mol. Diversity 2010, 14, 869-868.

27. Continuous Flow Organic Synthesis Under High Temperature/Pressure Conditions.
T. Razzaq, C.O. Kappe
Chem. Asian J. 2010, 5, 1274-1289.

26. Heterocyclic BINAP Analogues.
N. Arshad, C. O. Kappe
Adv. Heterocycl. Chem. 2010, 99, 33-59.

25. Click Chemistry under Non-classical Reaction Conditions.
C.O. Kappe, E. Van der Eycken
Chem. Sov. Rev. 2010, 39, 1280-1290.

24. Controlled Microwave Heating in Modern Organic Synthesis. Highlights from the 2004-2008 Literature.
C. O. Kappe, D. Dallinger
Mol. Diversity 2009, 13, 71-193.

23. The Liebeskind-Srogl C-C Cross-Coupling Reaction.
H. Prokopcova, C.O. Kappe
Angew. Chem. Int. Ed. 2009, 48, 2276.

22. Microwave Dielectric Heating in Synthetic Organic Chemistry.
C.O. Kappe
Chem. Sov. Rev. 2008, 37, 1127-1139.

21. Copper-Catalyzed C-C Coupling of Thiol Esters and Boronic Acids under Aerobic Conditions.H. Prokopcova, C.O. Kappe
Angew. Chem. Int. Ed. 2008, 47, 3674-3677.

20. Parallel Processing of Microwave-Assisted Organic Transformations.
M. Matloobi, C.O. Kappe
Comb. Chem. High Throughp. Screening 2007, 10, 735-750.

19. Microwave-Assisted Synthesis in Water as Solvent.
D. Dallinger, C.O. Kappe
Chem. Rev. 2007, 107, 2563-2591.

18. Microwave Synthesis in High-Throughput Environments. Moving from Automated Sequential to Microtiter Plate Formats.
M. Matloobi, C.O. Kappe
Chim. Oggi 2007, 25, 26-31.

17. Microwave-Assisted Synthesis under Continuous Flow Conditions.
T. N. Glasnov, C.O. Kappe
Macromol. Rapid Commun. 2007, 28, 395-410.

16. The Use of Microwave Irradiation in Organic Synthesis. From Laboratory Curiosity to Standard Practice in Twenty Years.
C.O. Kappe
Chimia 2006, 60, 308-312.

15. The Impact of Microwave Synthesis on Drug Discovery.
C.O. Kappe, D. Dallinger
Nature Rev. Drug. Discov. 2006, 5, 51-63.

14. Creating Chemical Diversity Space by Scaffold Decoration of Dihydropyrimidines.
D. Dallinger, C.O. Kappe
Pure Appl. Chem. 2005, 77, 155-161.

13. Controlled Microwave Heating in Modern Organic Synthesis.
C.O. Kappe
Angew. Chem. Int. Ed. 2004, 43, 6250-6284.

12. Solid- and Solution-Phase Synthesis of Bioactive Dihydropyrimidines.
D. Dallinger, A. Stadler, C.O. Kappe
Pure Appl. Chem. 2004, 76, 1017-1024.

11. The Generation of Dihydropyrimidine Libraries Utilizing Biginelli Multicomponent Chemistry.
C.O. Kappe
QSAR Comb. Sci. 2003, 22, 630-645.

10. High-Speed Combinatorial Synthetics Utilizing Microwave Irradiation.
C.O. Kappe
Curr. Opin. Chem. Biol. 2002, 6, 314-320.

9. On the Chemistry of Stable a-Oxoketenes.
G. Kolenz, W. Heilmayer, C.O. Kappe, B. Wallfish, C. Wentrup
Croat. Chim. Acta 2001, 74, 815-823.

8. Speeding Up Solid-Phase Chemistry by Microwave Irradiation. A New Tool for High-Throughput Synthesis.
C.O. Kappe
American Laboratory 2001, 33(10), 13-19.

7. Biologically Active Dihydripyrimidones of the Bignelli-Type. A Literature Survey.
C.O. Kappe
Eur. J. Med. Chem. 2000, 35, 1043-1052.

6. Recent Advances in the Biginelli Dihydropyrimidine Synthesis. New Tricks from an Old Dog.
C.O. Kappe
Acc. Chem. Res. 2000, 33, 879-888.

5. Perfluorinated Acyl(Aroyl)pyruvates as Building Blocks for the Synthesis of Heterocycles.
V.I. Saloutin, Y.U. Burgart, C.O. Kappe, O.N. Chupakhin
Heterocycles 2000, 52, 1411-1434.

4. 4-Aryldihydropyrimidines via the Biginelli Condensation: Aza-Analogs of Niffedipine-Type Calcium Channel Modulators.
C.O. Kappe
Molecules 1998, 3, 1-9.

3. Synthetic Applications of Furan Diels-Alder Chemistry
C.O. Kappe, S. Murphree, A. Padwa
Tetrahedron 1997, 53, 14179-14233 (Tetrahedron Report Number 430)

2. The Use of 1,2-Shifts in Carbenes and Nitrenes in the Generation of Novel Heterocumulenes.
C. Wentrup, C.O. Kappe, M.W. Wong
Pure Appl. Chem. 1995, 67, 749-754. 

1. 100 Years of the Biginelli Dihydropyrimidine Synthesis.
C.O. Kappe
Tetrahedron 1993, 49, 6937-6963 (Tetrahedron Report Number 336).

 

Univ.-Prof. Mag. Dr.rer.nat.

Christian Oliver Kappe

Univ.-Prof. Mag. Dr.rer.nat. Christian Oliver Kappe Institut für Chemie

Institut für Chemie

Telefon:+43 316 380 - 5352
Fax:+43 (0)316 380 - 9840

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