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1. An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization

Rial-Rodríguez, E.; Williams, J. D.; Cantillo, D.; Fuchß, T.; Sommer, A.; Eggenweiler, H.-M.; Kappe, C. O.; Laudadio, G.
ChemRxiv, 2024, 10.26434/chemrxiv-2024-dm4zj.

Previous Publications

26. Synthesis of Unnatural Amino Acids via Ni/Ag-Electrocatalytic Cross-Coupling

Laudadio, G.†; Neigenfind, P.†; Chebolu, R.; Blasczak, V. D.; Maddirala, S. J.; Palkowitz, M. D.; Bolduc, P. N.; Nicastri, M. C.; Puthukanoori, R. K.; Paraselli, B. R.; Baran, P. S.
Org. Lett.
, 2024, 26, 2276–2281.

25. Nickel-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers

Laudadio, G.†; Neigenfind, P.†; Péter, Á.†; Rubel, C. Z.; Emmanuel, M. A.; Oderinde, M. S.; El-Hayek Ewing, T.; Palkowitz, M. D.; Sloane, J. L.; Gillman, K. W.; Ridge, D.; Bolduc, P. N.; Nicastri, M. C.; Zhang, B.; Clementson, S.; Nasser Petersen, N.; Martín-Gago, P.; Mykhailiuk, P.; Engle, K. M.; Baran, P. S.
Angew. Chem. Int. Ed., 2024, 63, e202314617. (Selected as Very Important Paper, Highlighted by Organic Process Research & Development, Synfacts)

24. Electroreductive Synthesis of Nickel(0) Complexes

Rubel, C.; Cao, Y.; El-Hayek Ewing, T.; Laudadio, G.; Beutner, G.; Wisniewski, S. R.; Wu, X.; Baran, P. S.; Vantourout, J. C.; Engle, K. M.
Angew. Chem. Int. Ed.2024, 63, e202311557. (Selected as Hot Paper, Highlighted by Organic Process Research & Development)

23. Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling

Zhang, B.; He, J.; Gao, Y; Levy, L.; Oderinde, M. S.; Palkowitz, M. D.; Murali Dhar, T. G.; Mandler, M. D.; Collins, M. R.; Schmitt, D. C.; Bolduc, P. N.; Chen T.; Clementson, S.; Nasser Petersen, N.; Laudadio, G.; Bi, C.; Kawamata, Y.; Baran, P. S.
Nature, 2023, 623, 745-751.

22. Decarboxylative Cross-Coupling: A Radical Tool In Medicinal Chemistry

Laudadio, G.†; Palkowitz, M. D.†; El-Hayek Ewing, T.; Baran, P. S. 
ACS Med. Chem. Lett., 2022, 13, 1413-1420. (Highlighted by Synfacts)

21. Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis

Palkowitz, M. D.†; Laudadio, G.†; Kolb, S.; Choi, J.; Oderinde, M. S.; El-Hayek Ewing, T.; Bolduc, P. N.; Chen, T.; Zhang, H.; Cheng, P. T. W.; Zhang, B.; Mandler, M. D.; Richter, J. M.; Collins, M. R.; Schioldager, R. L.; Murali Dhar, M.; Vokits, B.; Zhu, Y.; Echeverria, P. G.; Poss, M. A.; Shaw, S. A.; Clementson, S.; Nasser Petersen, N.; Mykhailiuk, P.; Baran, P. S. 
J. Am. Chem. Soc., 2022, 144, 17709-17720. (Top 5 most read paper of September 2022, Highlighted by Organic Process Research & Development)

20. Accelerated and Scalable C(sp3)−H Amination via Decatungstate Photocatalysis using a Flow Photoreactor equipped with High-Intensity LEDs

Wan, T.; Wen, Z.; Laudadio, G.; Capaldo, L.; Lammers, L.; Rincon, J.; Garcia-Losada, P.; Mateos, C.; Frederick, M. O.; Broersma, R.; Noël, T.
ACS Cent. Sci., 2022, 8, 51-56

19. Practical and Regioselective Synthesis of C-4-Alkylated Pyridines

Choi, J.; Laudadio, G.; Godineau, E.; Baran, P. S.
J. Am. Chem. Soc., 2021, 143, 11927-11933. (Top 5 most read paper of August 2021, Most cited article JACS 2020-2021, Highlighted by Organic Process Research & Development)

18. Decatungstate-mediated C(sp3)‒H Heteroarylation via Radical-Polar Crossover in Batch and Flow

Wan, T.; Capaldo, L.; Laudadio, G.; Nyunchev, A.; Rincon, J.; Garcia-Losada, P.; Gutierrez, C. M.; Frederick, M. O.; Nuño, M.; Noël, T.
Angew. Chem. Int. Ed., 2021, 60, 17893-17897. (Top downloaded article 2022, Highlighted by Synfacts)

17. β-Zeolite Assisted Lignin-First Fractionation in a Flow-Through Reactor

Kramarenko, A.; Etit, D.; Laudadio, G.; D’Angelo, F. N.
ChemSusChem, 2021, 14, 3838-3849. (Inner Cover)

16. Electrochemical Aziridination of Internal Alkenes with Primary Amines

Ošeka, M.†; Laudadio, G.†; van Leest, N. P.; Dyga, M.; de Andrade Bartolomeu, A.; Gooßen, L. J.; de Bruin, B.; de Oliveira, K. T.; Noël, T.
Chem, 2021, 7, 255-266.

15. Optimization of a Decatungstate-Catalyzed C(sp3)–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor

Wen, Z.; Maheshwari, A.; Sambiagio, C.; Deng, Y.; Laudadio, G.; Van Aken, K.; Sun, Y.; Gemoets, H. P. L.; Noël T.
Org. Process Res. Dev., 2020, 24, 2356-2361.

14. C(sp3)–H functionalizations of light hydrocarbons using decatungstate photocatalysis in flow

Laudadio, G.†; Deng, Y.†; van der Waal, K.; Ravelli, D.; Nuño, M.; Fagnoni, M.; Guthrie, D.; Sun, Y.; Noël, T. 
Science, 2020, 369, 92-96. (Highlighted by Chemical & Engineering News, Chemistry World, Synfacts, Synform, Hepatochem - The 20 Must Read Photochemistry Papers from 2020)

13. Accelerating sulfonyl fluoride synthesis through electrochemical oxidative coupling of thiols and potassium fluoride in flow

Cao, Y.; Adriaenssens, B.; de Andrade Bartolomeu, A.; Laudadio, G.; de Oliveira, K. T.; Noël, T.
J. Flow Chem., 2020, 10, 191-197.

12. Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes

Hell, S. H.; Meyer, C. F.; Laudadio, G.; Misale, A.; Willis M. C.; Noël, T.; Trabanco, A. A.; Gouverneur, V.
J. Am. Chem. Soc., 2020, 142, 720-725.

11. The Fundamentals Behind the Use of Flow Reactors in Electrochemistry

Noël, T.; Cao, Y.; Laudadio, G.
Acc. Chem. Res., 2019, 52, 2858-2869. (Highlighted by Organic Process Research & Development)

10. Sulfonyl Fluoride Synthesis through Electrochemical Oxidative Coupling of Thiols and Potassium Fluoride

Laudadio, G.†; de Andrade Bartolomeu, A.†; Verwijlen, L. M. H. M.; Cao, Y.; de Oliveira, K. T.; Noël, T. 
J. Am. Chem. Soc., 2019, 141, 11832-11836. (Highlighted by Synfacts)

9. Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols

Laudadio, G.; Barmpoutsis, E.; Schotten, C.; Struik, L.; Govaerts, S.; Browne, D.L.; Noël T. 
J. Am. Chem. Soc., 2019, 141, 5664-5668. (Highlighted by Organic Process Research & Development)

8. Synthesis of Pterostilbene through supported-catalyst promoted Mizoroki-Heck reaction, and its transposition in continuous flow reactor

Laudadio, G.; Fusini, G.; Casotti, G.; Evangelisti, C.; Angelici, G.; Carpita, A.
J. Flow Chem., 2019, 9, 133-143.

7. Design and application of a modular and scalable electrochemical flow microreactor

Laudadio, G.; de Smet, W.; Struik, L.; Cao, Y.; Noël, T.
J. Flow Chem., 2018, 8, 157–165.

6. Biocatalytic synthesis of the Green Note trans-2-hexenal in a continuous-flow microreactor

van Schie, M. M. C. H.; Pedroso de Almeida, T.; Laudadio, G.; Tieves, F.; Fernández-Fueyo, E.; Noël, T.; Arends, I. W. C. E.; Hollmann F.
Beilstein J. Org. Chem., 2018, 14, 697-703.

5. Selective sp3 C-H Aerobic Oxidation enabled by Decatungstate Photocatalysis in Flow

Laudadio, G.; Govaerts, S.; Wang, Y.; Ravelli, D.; Koolman, H.; Fagnoni, M.; Djuric, S.; Noël, T.
Angew. Chem. Int. Ed., 2018, 130, 4142-4146.

4. An environmentally benign and selective electrochemical oxidation of sulfides and thiols in a continuous-flow microreactor

Laudadio, G.; Straathof, N. J. W.; Lanting, M. D.; Knoops, B.; Hessel, V.; Noël, T.
Green Chem., 2017, 19, 4061-4066. (2017 Green Chemistry Hot Articles)

3. Flow Synthesis of Diaryliodonium Triflates

Laudadio, G.†; Gemoets, H. P. L.†; Hessel, V.; Noël, T.
J. Org. Chem., 2017, 82, 11735-11741. (Highlighted by Organic Process Research & Development)

2. A Modular Flow Design for the meta-Selective C-H Arylation of Anilines

Gemoets, H. P. L.†; Laudadio, G.†; Verstraete, K.; Hessel, V.; Noël, T.
Angew. Chem. Int. Ed., 2017, 56, 7161-7165.

1. Safety assessment in development and operation of modular continuous-flow processes

Kockmann, N.; Thenée, P.; Fleischer-Trebes, C.; Laudadio, G.; and Noël, T.
React. Chem. Eng., 2017, 2, 258-280. (Highlighted by Reaction Chemistry & Engineering Emerging Investigators 2017, RCE most-read Q3 2017)


Gabriele Laudadio

Institut für Chemie

Institut für Chemie

Telefon:+43 316 380 - 8679



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