Original Articles

315. Generation of Anhydrous Diazomethane on Lab Scale Using Membrane Separation Technology
D. Dallinger, C. O. Kappe
Nature Prot. 2017, 12, 2138-2147.

314. Integration of Bromine and Cyanogen Bromide Generators for the Telescoped Continuous Synthesis of Cyclic Guanidines
G. Glotz, R. Lebel, D. Dallinger, C. O. Kappe
Angew. Chem. Int. Ed. 2017, 56, 13786-13789.

313. Synthesis of Mepivacaine and its Analogues by a Continuous Flow Tandem Hydrogenation−Reductive Amination Strategy
N.S. Suveges, R. O. M. A. de Souza, B. Gutmann, C. O. Kappe
Eur. J. Org. Chem. 2017, 24, in press.

312. An Integrated Continuous Flow Synthesis of a Key Oxazolidine Intermediate to Noroxymorphone from Naturally Occurring Opioids
A. Mata, D. Cantillo, C. O. Kappe
Eur. J. Org. Chem. 2017, 24, in press.

311. Continuous Flow Synthesis of Carbonylated Heterocycles via Pd-Catalyzed Oxidative Carbonylation Using CO and O₂ at Elevated Temperature and Pressure
Y. Chen, C. A. Hone, B. Gutmann, C. O. Kappe
Org. Process Res. Dev. 2017, 21, 1080-1087.

310. Development of a Continuous-Flow Sonogashira Cross-Coupling Protocol using Propyne Gas under Process Intensified Conditions
D. Znidar, C. Hone, P. Inglesby, A. Boyd, C. O. Kappe
Org. Process Res. Dev. 2017, 21, 878-884.

309. Development of a Continuous-Flow Process for a Pd-Catalyzed Olefin Cleavage using Oxygen within the Explosive Regime
C. Hone, A O’Kearney-McMullan, R. Munday, C. O. Kappe
ChemCatChem 2017, 9, 3298-3302.

308. Continuous Flow Difluoromethylation with Chlorodifluoromethane under Biphasic Conditions
B. Gutmann, P. Hanselmann, M. Bersier, D. Roberge, C. O. Kappe
J. Flow. Chem. 2017, 7, 46-51.

307. Hydrogen Sulfide Chemistry in Continuous Flow: Efficient Synthesis of 2-Oxopropanethioamide
D. Cantillo, P. A. Inglesby, A. Boyd, C. O. Kappe
J. Flow. Chem. 2017, 7, 29-32.

306. Reaction Calorimetry in Microreactor Environments – Measuring Heat of Reaction by Isothermal Heat Flux Calorimetry
G. Glotz, D. Knoechel, P. Podmore, H. Gruber-Woelfler, C. O. Kappe
Org. Process Res. Dev. 2017, 21, 10469-10478.

305. Continuous Flow Synthesis of Indoles by Pd-catalyzed Deoxygenation of 2-Nitrostilbenes with Carbon Monoxide
G. Glotz, B. Gutmann, P. Hanselmann, A. Kulesza, D. Roberge, C. O. Kappe
RSC Adv. 2017, 7, 10469-10478.

304. Continuous Flow Synthesis of a Key 1,4-Benzoxazinone Intermediate via a Nitration/Hydrogenation/Cyclization Sequence
D. Cantillo, B. Wolf, R. Goetz, C. O. Kappe
Org. Process Res. Dev. 2017, 21, 125-132.

303. Design and Development of Pd-catalyzed Aerobic N-Demethylation Strategies for the Synthesis of Noroxymorphone in Continuous Flow Mode

B. Gutmann, D. Cantillo, U. Weigl, D. P. Cox, C. O. Kappe
Eur. J. Org. Chem. 2017, 914-927. 

302. Continuous Flow Homolytic Aromatic Substitution with Electrophilic Radicals – A Fast and Scalable Protocol for Trifluoromethylation
J. L. Monteiro, P. F. Carneiro, P. Elsner, D. Roberge, P. G. M. Wuts, K. Kurjan, B. Gutmann, C. O. Kappe
Chem. Eur. J. 2017, 23, 176-186.

301. Design and Performance Validation of a Conductively Heated Sealed Vessel Reactor for Organic Synthesis
D. Obermayer, D. Znidar, G. Glotz, A. Stadler, D. Dallinger, C. O. Kappe
J. Org. Chem. 2016, 81, 11788-11801.

300. Continuous-Flow Electrophilic Amination of Arenes and Schmidt Reaction of Carboxylic Acids Utilizing the Superacidic Trimethylsilyl Azide/Triflic Acid Reagent SystemY. Chen, B. Gutmann, C. O. Kappe
J. Org. Chem. 2016, 81, 9372-9380.

299. A Laboratory-Scale Continuous Flow Chlorine Generator for Organic Synthesis
F. J. Strauss, D. Cantillo,  J. Guerra, C. O. Kappe
React. Chem. Eng. 2016, 1, 472-476.

298. Towards the Synthesis of Noroxymorphone via Aerobic Palladium-Catalyzed Continuous Flow N-Demethylation Strategies.
B. Gutmann, P. Elsner, D. P. Cox, U. Weigl, D. M. Roberge, C. O. Kappe
ACS Sust. Chem. Eng. 2016, 4, 6048-6061.

297. A Laboratory Scale Reactor for the Generation of Anhydrous Diazomethane
D. Dallinger, V. D. Pinho, B. Gutmann, C. O. Kappe
J. Org. Chem. 2016, 81, 5814-5823.

296. Batch and Continuous Flow Aerobic Oxidation of 14-Hydroxy Opioids to 1,3-Oxazolidines - A Concise Synthesis of Noroxymorphone
B. Gutmann, U. Weigl, D. P. Cox, C. O. Kappe
Chem. Eur. J. 2016, 22, 10393-10398

295. Visible-Light Photoredox Catalysis using a Macromolecular Ruthenium Complex: Reactivity andRecovery by Size-Exclusion Nanofiltration in Continuous Flow
J. Guerra, D. Cantillo, C. O. Kappe
Catal. Sci. Technol. 2016, 6, 4695-4699.

294. One-Pot Synthesis of alpha-Haloketones Employing a Membrane-Based Semi-Batch Diazomethane Generator
S. Garbarino, J. Guerra, P. Poechlauer, B. Gutmann, C. O. Kappe,
J. Flow Chem. 2016, 6, 211-217.

293. Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies
B. Pieber, C. O. Kappe,
Org. Lett. 2016, 18, 1076−1079.

292. Selective Olefin Reduction in Thebaine Using Hydrazine Hydrate and O2 under Intensified Continuous Flow Conditions
B. Pieber, D. P. Cox, C. O. Kappe
Org. Process Res. Develop. 2016, 20, 376−385.

291. Copper/Nafion-Catalyzed Hydroarylation Process Involving Ketenimine Intermediates: A Novel and Synthetic Approach to 4-Sulfonamidoquinoline-2-ones and Derivatives Thereof
B. Reichart, G. Guedes de la Cruz, K. Zangger, C. O. Kappe, T. Glasnov
Adv. Synth. Catal. 2016, 358, 50–55.

290. Safe Generation and Use of Bromine Azide under Continuous Flow Conditions  ̶  Selective 1,2-Bromoazidation of Olefines
D. Cantillo, B. Gutmann, C. O. Kappe
Org. Biomol. Chem. 2016, 14, 853-857.

289. Diazo-strategy for the Synthesis of Pyridazines: Pivotal Impact of Diazo Precursor Configuration on the Process
V.A. Nikolaev, D. Cantillo, C. O. Kappe, J.J. Medvedev, G.K.S. Prakash, M.S. Supurgibekov
Chem. Eur. J. 2016, 22, 174-184.

288. Continuous Synthesis of Hydantoins: Intensifying the Bucherer-Bergs Reaction
J. L. Monteiro, B. Pieber, A. G. Corrêa, C. O. Kappe,
Synlett 2016, 27, 83-87.
 
 

287. Process Intensified Flow Synthesis of 1H-4-Substituted Imidazoles: Toward the Continuous Production of Daclatasvir

P. F. Carneiro, B. Gutmann, R. O. M. A. de  Souza, C. O. Kappe

ACS Sust. Chem. Eng. 2015, 3, 3445−3453.

286. Development of a Continuous Flow Sulfoxide Imidation Protocol Using Azide Sources under Superacidic Conditions

B. Gutmann, P. Elsner, A. O'Kearney-McMullan, W. Goundry, D. M. Roberge, C. O. Kappe

Org. Process Res. Develop. 2015, 19, 1062-1067.

285. Light-Induced C−H Arylation of (Hetero)arenes via In Situ Generated Diazo Anhydrides

D. Cantillo, C. Mateos , J. A. Rincon, O. de Frutos, C. O. Kappe,

Chem. Eur. J. 2015, 21, 12894-12898.

284. A Sequential Ugi Multicomponent/Cu-Catalyzed Azide-Alkyne Cycloaddition Approach for the Continuous Flow Generation of Cyclic Peptoids

C. E. M. Salvador, B. Pieber, P. M. Neu, A. Torvisco, C. K. Z. Andrade, C. O. Kappe,

J. Org. Chem. 2015, 80, 4590-4602.

283.TRPC3 Controls Cardiac Contractility Andarrhythmogenesis by Interaction with NCX1

B. Doleschal, G. Wölkart, S. Wolf, M. Schernthaner, M. Lichtenegger, T. N. Glasnov, C. O. Kappe, B. Mayer, G. Antoons, F. Heinzel, K. Groschner.

Cardiovascular Res. 2015, 106, 163-173.

282.Nafion-H Catalyzed High-Temperature/High-Pressure Synthesis of a Triarylmethane in Continuous Flow Mode

S. Hayden, T. Glasnov, C. O. Kappe,

Chem. Eng. Technol. 2015, 38, 1743-1748.

281.Benchmarking Immobilized Di- and Triarylphosphine Palladium Catalysts for Continuous Flow Cross-Coupling Reactions: Efficiency, Durability and Metal Leaching Studies

R. Greco, W. Goessler, D. Cantillo, C. O. Kappe,

ACS Catalysis 2015, 5, 1303-1312.

280. Chiral Chlorohydrins via Biocatalyzed Reductions of Chloroketones: Chiral Building Blocks for Antiretroviral Drugs

A. S. de Miranda, R. C. Simon, B. Grischek, G. C. de Paula, B. A. C. Horta, L. S. M. e Miranda, W. Kroutil, C. O. Kappe, R O. M. A. de Souza

ChemCatChem 2015, 7, 984-992.

279. Covalent Adduct Formation Between the Plasmalogen-derived Modification Product 2-
Chlorohexadecanal and Phloretin

A. Üllen, C. Nusshold, T. Glasnov, R. Saf, D. Cantillo, G. Eibinger, H. Reicher, G. Fauler, E. Bernhart, S. Hallstrom, N. Kogelnik, K. Zangger, C. O. Kappe, E. Malle, W. Sattler

Biochem. Pharmacol. 2015, 93, 470-481.

278. Continuous Flow Reduction of Artemisinic Acid Utilizing Multi-Injection Strategies – Closing the Gap Towards a Fully Continuous Synthesis of Antimalarial Drugs

B. Pieber, T. Glasnov, C. O. Kappe,

Chem. Eur. J. 2015, 21, 4368-4376.

277. A Detailed Investigation of the Multicomponent Reaction of Salicylaldehyde, Ethyl acetoacetate and Isocyanides under Microwave Heating

T. Amanpour, K. Zangger, F. Belaj, A. Bazgir, D. Dallinger, C. O. Kappe

Tetrahedron 2015, 71, 7159-7169.

276. Singlet Oxygen Oxidation of 5-Hydroxymethylfurfural (5-HMF) in Continuous Flow.

T. S. A. Heugebaert, C. V. Stevens, C. O. Kappe,

ChemSusChem 2015, 8, 1648-1651.

275. Continuous Flow Preparation of Supported Iron Oxide Nanoparticles on Porous Silicates

A. Yepez, F. L.Y. Lam, A. A. Romero, C. O. Kappe, R. Luque,

ChemCatChem 2015, 7, 276–282.

274. A Continuous Flow Protocol for Light-Induced Benzylic Fluorination.

D. Cantillo, O. de Frutos, J. A. Rincon, C. Mateos , C. O. Kappe,

J. Org. Chem. 2014, 79, 8486-8490.

273. Continuous Flow Synthesis of beta-Amino Acids from alpha-Amino Acids via Arndt-Eistert Homologation.

V. D. Pinho, B. Gutmann, C. O. Kappe,

RSC Adv. 2014, 4, 37419-37422.

272. Shifting Chemical Equilibria in Flow – Efficient Decarbonylation Chemistry Driven by Annular Flow Regimes.
B. Gutmann, P. Elsner, T. Glasnov, D. M. Roberge, C. O. Kappe,

Angew. Chem. Int. Ed. 2014, 53, 11557-11561.

271.A Critical Investigation on the Occurrence of Microwave Effects in Emulsion Polymerizations.

S. Hayden, A. F. H. Studentschnig, S. Schober, C. O. Kappe,

Macromol. Chem. Phys. 2014, 215, 2318-2326.

270.Immobilized Iron Oxide Nanoparticles as Stable and Reusable Catalysts for Hydrazine-mediated Nitro Reductions in Continuous Flow

M. Mirhosseini Moghaddam, B. Pieber, T. Glasnov, C. O. Kappe,

ChemSusChem 2014, 7, 3122-3131.

269. A Sequential Nitration/Hydrogenation Protocol for the Synthesis of Triaminophloroglucinol − Safe Generation and Use of an Explosive Intermediate under Continuous Flow Conditions

D. Cantillo, M. Damm, D. Dallinger, M. Bauser, M. Berger, C. O. Kappe

Org. Process Res. Develop. 2014, 18, 1360-1366.

268. Chemistry of Pyrrolizidine Alkaloids Revisited – Semi-Synthetic Microwave and Continuous-Flow Approaches towards Crotalaria-Alkaloids.

S. T. Martinez, A. C. Pinto, T. Glasnov, C. O. Kappe

Tetrahedron Lett. 2014, 55, 4181-4184.

267. Regulation of Gene Expression through a Transcriptional Repressor that Senses Acylchain Length in Membrane Phospholipids.

H. F. Hofbauer, F. H. Schopf, H. Schleifer, O. L. Knittelfelder, B. Pieber, G. N. Rechberger, H. Wolinski, M. L. Gaspar, C. O. Kappe, J. Stadlmann, K. Mechtler, A. Zenz, K. Lohner, O. Tehlivets, S. A. Henry, S. D. Kohlwein,

Dev. Cell 2014, 29, 729.

266. Combined Batch and Continuous Flow Procedure to the Chemo-Enzymatic Synthesis of Biaryl Moiety of Odanacatib.

R. de Oliveira Lopes, A. S. de Miranda, B. Reichart, T. Glasnov, C. O. Kappe, R. C. Simon, W. Kroutil, L. S. M. Miranda, I. C. R.Leal, R. O. M. A. de Souza,

J. Mol. Catal. B. 2014, 104, 101-107.

265. A Critical Investigation on the Existence of Selective Microwave Absorption in the Synthesis of CdSe Quantum Dots.

M. M. Moghaddam, C. O. Kappe,

Aust. J. Chem. 2014, 67, 1180-1188.

264. Flash Carboxylation: Fast Lithiation - Carboxylation Sequence at Room Temperature in Continuous Flow.

B. Pieber, T. Glasnov, C. O. Kappe,

RSC Adv. 2014, 4, 13430-13433.

263. Continuous Flow Synthesis of alpha-Haloketones – Essential Building Blocks of Antiretroviral Agents.

V. D. Pinho, B. Gutmann, L. S. M. Miranda, R. O. M. A. de Souza, C. O. Kappe,

J. Org. Chem. 2014, 79, 1555-1562.

262. Continuous Flow alpha-Trifluoromethylation of Ketones by Metal Free Visible Light Photoredox Catalysis.

D. Cantillo, O. de Frutos, J. A. Rincon, C. Mateos , C. O. Kappe,

Org. Lett. 2014, 17, 5590-5593.

261. A Microwave Approach to the Synthesis of Certain 4-Substituted Phenyl-6-phenyl-3-cyano-2-pyridones.

A. Marinković, D. Mijin, J. Mirković, V. Maslak, C. O. Kappe,

J. Serb. Chem. Soc. 2014, 79, 759-765.

260. A Scalable Procedure for Light Induced Benzylic Brominations in Continuous Flow.

D. Cantillo, O. de Frutos, J. A. Rincon, C. Mateos , C. O. Kappe,

J. Org. Chem. 2014, 79, 223-229.

259. Effect of Configuration of 2-Vinyldiazocarbonyl Compounds on the Ring Closure to Pyrazoles: Experimental and Computational Study.

M. B. Supurgibekov, D. Cantillo, C. O. Kappe, G. K. Surya Prakash, V. A. Nikolaev,

Org. Biomol. Chem. 2014, 12, 682-689.

258. Microwave Mediated Preparation of Nanoparticles from wx Corn Starch Employing Nanoprecipitation,

S. Juna, S. Hayden, M. Damm, C. O. Kappe, A. Huber,

Starch 2014, 66, 316-325.

257. Nanoprecipitaton of Native Pea Starches Treated in Alkaline Media at various Temperatures Employing a Dedicated Microwave Reactor

S. Juna, S. Hayden, M. Damm, C. O. Kappe, A. Huber,

Starch 2014, 66, 124-131.
 

256. Homogeneous Liquid-Phase Oxidation of Ethylbenzene to Acetophenone in Continuous Flow Mode,

B. Gutmann, P. Elsner, D. Roberge, C. O. Kappe,

ACS Catalysis 2013, 3, 2669-2676.

255. Continuous Flow Generation and Reactions of Anhydrous Diazomethane Using a Teflon AF 2400 Tube-in-Tube Reactor.

F. Mastronardi, B. Gutmann, C. O. Kappe,

Org. Lett. 2013, 16, 5590-5593.

254. Simulating Microwave Chemistry in a Resistance Heated Autoclave Made of Semiconducting Silicon Carbide Ceramic.

D. Obermayer, M. Damm, C. O. Kappe

Chem. Eur. J. 2013, 19, 15827-15830.

253. Direct Preparation of Nitriles from Carboxylic Acids in Continuous Flow

D. Cantillo, C. O. Kappe,

J. Org. Chem. 2013, 78, 10567-10571.

252. Phase-Transfer Catalysis – Mixing Effects in Continuous-Flow Liquid/Liquid O- and S-Alkylation Processes.

B. Reichart, C. O. Kappe, T. N. Glasnov,

Synlett 2013, 24, 2393-2396.

251. A Three Step Continuous Flow Synthesis of the Biaryl Unit of the HIV Protease Inhibitor Atazanavir

L. Dalla-Vechia, B. Reichart, T. Glasnov, L. S. M. Miranda, C. O. Kappe, R. O. M. A. de Souza,

Org. Biomol. Chem. 2013, 11, 6806-6813.

250. Continuous-flow Production of Photocatalytically Active Titanium Dioxide Nanocrystals and its Application to the Photocatalytic Addition of N,N-Dimethylaniline to N-Methylmaleimide.

M. Baghbanzadeh, T. N. Glasnov, C. O. Kappe,

J. Flow Chem. 2013, 3, 109-113.

249. In Situ Generation of Diimide from Hydrazine and Oxygen - Transfer Hydrogenation of Olefins in Continuous Flow.

B. Pieber, S. T. Martinez, D. Cantillo, C. O. Kappe,

Angew. Chem. Int. Ed. 2013, 52, 10241-10244.

248. Versatile Low-loaded Mechanochemically Synthesized Supported Iron Oxide Nanoparticles for Continuous Flow Alkylations

A. M. Balu, A. Pineda, D. Obermayer, A. A. Romero, C. O. Kappe, R. Luque,

RSC Adv. 2013, 3, 16292-16295.

247. Design and Evaluation of Improved Magnetic Stir Bars for Single-mode Microwave Reactors

D. Obermayer, M. Damm, C. O. Kappe,

Org. Biomol. Chem. 2013, 11, 4949-4956.

246. Continuous-flow Synthesis of CdSe Quantum Dots: A Size Tunable and Scalable Approach

M. M. Moghaddam, M. Baghbanzadeh, A. Sadeghpour, O. Glatter, C. O. Kappe,

Chem. Eur. J. 2013, 19, 11629-11636.

245. Hydrazine-Mediated Reduction of Nitro and Azide Functionalities Catalyzed by Highly Active and Reusable Magnetic Iron Oxide Nanocrystals.

D. Cantillo, M. Mirhosseini Moghaddam, C. O. Kappe,

J. Org. Chem. 2013, 78, 4530-4542.

244. Continuous Flow Synthesis of Adipic Acid from Cyclohexene Using Hydrogen Peroxide in High-Temperature Explosive Regimes.

M. Damm, B. Gutmann, C. O. Kappe,

ChemSusChem 2013, 6, 978-982.

243. Influence of Temperature on the Apparent Molar Masses and Sizes of Pregelatinised Wx Corn in Aqueous Media Determined Using Asymmetrical Flow Field-Flow Fractionation

S. Juna, S. Hayden, M. Damm, C. O. Kappe, A. Huber,

Starch 2013, 65, 954-961.

242. Nanocatalysis in Continuous Flow: Supported Iron Oxide Nanoparticles for the Heterogeneous Aerobic Oxidation of Benzyl Alcohol.

D. Obermayer, A. M. Balu, A. A. Romero, W. Goessler, R. Luque, C. O. Kappe,

Green Chem. 2013, 15, 1530-1537.

241. In-Situ Preparation and Characterization of Silver Nanocomposites on Cellulosic Fibers - Microwave vs. Conventional Heating

D. Breitwieser, M. Mirhosseini Moghaddam, S. Spirk, M. Baghbanzadeh, T. Pivec, H. Fasl, V. Ribitsch, C. O. Kappe,

Carbohydr. Polym. 2013, 94, 677-686.

240. On the Fischer Indole Synthesis of 7-Ethyltryptophol- Mechanistic and Process Intensification Studies under Continuous Flow Conditions

B. Gutmann, M. Gottsponer, P. Elsner, D. Cantillo, D. M. Roberge, C. O. Kappe

Org. Process Res. Develop. 2013, 17, 294-302.

239. Direct Aerobic Oxidation of 2-Benzylpyridines in a Gas-Liquid Continuous-Flow Regime Using Propylene Carbonate as Solvent.

B. Pieber, C. O. Kappe,

Green Chem. 2013, 15, 320-324.

238. A TRPC3 Blocker, Ethyl-1-(4-(2,3,3-Trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3), Prevents Stent-induced Arterial Remodeling.

S. Koenig, H. Maechler, G. Hoefler, C. O. Kappe, T. N. Glasnov, M. Braune, E. Wittchow, K. Groschner

J. Pharmacol. Exp. Therap. 2013, 344, 30-40.

237. Continuous Flow Synthesis of n-Alkyl Chlorides in a High-Temperature Microreactor Environment.

B. Reichart, G. Tekautz, C. O. Kappe,

Org. Process Res. Develop. 2013, 17, 152-157.

236. On the Importance of Accurate Internal Temperature Measurements in the Microwave Dielectric Heating of Viscous Systems and Polymer Synthesis.

S. Hayden, M. Damm, C. O. Kappe,

Macromol. Chem. Phys. 2013, 214, 423-434. 

235. An Experimental and Computational Assessment of Acid-Catalyzed Azide-Nitrile Cycloadditions.

D. Cantillo, B. Gutmann, C. O. Kappe,

J. Org. Chem. 2012, 77, 10882−10890.

234. On the Mechanism of the Dakin-West Reaction.

L. Dalla-Vechia, V. G. Santos, M. N. Godoi, D. Cantillo, C. O. Kappe, M. N. Eberlin, R. O. M. A. de Souza, L. S. M. Miranda,

Org. Biomol. Chem. 2012, 10, 9013-9020.

233. Microwave-assisted Synthesis of CdSe Quantum Dots: Can the Electromagnetic Field Influence the Formation and Quality of the Resulting Nanocrystals?

M. Mirhosseini Moghaddam, M. Baghbanzadeh, A. Keilbach, C. O Kappe,

Nanoscale 2012, 4. 7435-7442.

232. Methylation Using Dimethylcarbonate Catalysed by Ionic Liquids Under Continuous Flow Conditions.

T. N. Glasnov, J. D. Holbrey, C. O. Kappe, K. R. Seddon, T. Yan,

Green Chem. 2012, 14, 3071-3076.

231. In Situ Generated Iron Oxide Nanocrystals as Efficient and Selective Catalysts for the Reduction of Nitroarenes in Continuous Flow.

D. Cantillo, M. Baghbanzadeh, C. O. Kappe,

Angew. Chem. Int. Ed. 2012, 51, 10190-10193.

230. Novel Pyrazole Compounds for Pharmacological Discrimination Between
Receptor-operated and Store-operated Ca2+ Entry Pathways.

H. Schleifer, B. Doleschal, M. Lichtenegger, R. Oppenrieder, I. Derler, I. Frischauf, T. N.
Glasnov, C. O. Kappe, C. Romanin, K. Groschner

Br. J. Pharmacol. 2012, 167, 1712–1722.

229. Can Electromagnetic Fields Influence the Structure and Enzymatic Digest of Proteins? A Critical Evaluation of Microwave-Assisted Proteomics Protocols

M. Damm, C. Nusshold, D. Cantillo, G. N. Rechberger, K. Gruber, W. Sattler, C. O. Kappe,

J. Proteom. 2012, 75, 5533-5543.

228. Microwave-assisted Continuous Flow Synthesis on Industrial Scale.

R. Morschhäuser, M. Krull, C. Kayser, C. Boberski, R. Bierbaum, P. A. Püschner, T. N. Glasnov, C. O. Kappe,

Green Process. Synthesis 2012, 1, 281-290.

227. High-Speed Microwave-assisted Synthesis of SEA0400 – a Selective Inhibitor of the Na+/Ca2+ Exchanger.

G. Guedes de la Cruz, K. Groschner, C. O. Kappe, T. N. Glasnov

Tetrahedron Lett. 2012, 53, 3731-3734.

226. Copper-Catalyzed C-O Bond Formation by Direct alpha-C-H Bond Activation of Ethers Using Stoichiometric Amounts of Peroxide in Batch and Continuous Flow Formats.

G. S. Kumar, B. Pieber, K. R. Reddy, C. O. Kappe,

Chem. Eur. J. 2012, 18, 6124-6128.

225. Treatment of Aqueous Waxy Corn Starch Dispersions in a Dedicated Microwave Reactor and
their Hydrodynamic Properties Determined Using Asymmetrical Flow Field-Flow Fractionation.

S. Juna, A. Huber, M. Damm, C. O. Kappe,

Starch 2012, 64, 652-656.

224. Flash Flow Pyrolysis: Mimicking Flash Vacuum Pyrolysis in a High-Temperature/High-Pressure Liquid-Phase Microreactor Environment.

D. Cantillo, H. Sheibani, C. O. Kappe,

J. Org. Chem. 2012, 77, 2463-2473.

223. Safe Generation and Synthetic Utilization of Hydrazoic Acid in a Continuous Flow Reactor

B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe,

J. Flow Chem. 2012, 2, 8-19.

222. A Critical Assessment of the Specific Role of Microwave Irradiation in the Synthesis of ZnO Micro- and Nano-structured Materials

M. Baghbanzadeh, S. D. Škapin, Z. C. Orel, C. O. Kappe,

Chem. Eur. J. 2012, 18, 5724-5731.

221. Direct Arylation of Benzene with Aryl Bromides Using High-Temperature/High-Pressure Process Windows – Expanding the Scope of C-H Activation Chemistry

B. Pieber, D. Cantillo, C. O. Kappe

Chem. Eur. J. 2012, 18, 5047-5055.

220. Characterization of Microwave-induced Electric Discharge Phenomena in Metal-Solvent Mixture.

W. Chen, B. Gutmann, C. O. Kappe,

ChemistryOpen 2012, 1, 39-48.

219. High-Temperature Continuous Flow Synthesis of 1,3,4-Oxadiazoles via N-Acylation of 5-Substituted Tetrazoles.

B. Reichart, C. O. Kappe,

Tetrahedron Lett. 2012, 53, 952-955.

218. A Critical Investigation on the Microwave-Assisted Preparation of Supported Iron Oxide Nanoparticles on Silica-type Mesoporous Materials.

A. M. Balu, D. Dallinger, D. Obermayer, J. M. Campelo, A. A. Romero, D. Carmona, F. Balas, J. Santamaria, K. Yohida, P. L. Gai, C. Vargas, C. O. Kappe, R. Luque,

Green Chem. 2012, 14, 393-402.

217. A Two-Step Continuous Flow Synthesis of N-(2-Aminoethyl)acylamides via Ring-Opening/Hydrogenation of Oxazolines.
B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe,
Chem. Eur. J. 2011, 17, 13146–13150.
 
216. A High-Throughput Platform for Low-Volume High-Temperature/Pressure Sealed Vessel Solvent Extractions.
M. Damm, C. O. Kappe,
Anal. Chim. Acta 2011, 707, 76-83.

215. Palladium-Catalyzed Direct Arylation of Heteroaromatic Compounds: Improved Conditions Utilizing Controlled Microwave Heating.
M. Baghbanzadeh, C. Pilger, C. O. Kappe,
J. Org. Chem. 2011, 76, 8138-8142.
 
214. Microwave-assisted Grafting to MCM-41 Silica and its Application as Catalyst in Flow Chemistry.
M. Oliverio, A. Procopio, T. N. Glasnov, W. Goessler, C. O. Kappe,
Aust. J. Chem. 2011, 64, 1522-1529.

213. Microwave-assisted Forced Degradation Using High-Throughput Microtiter Platforms.
B. Prekodravac, M. Damm, C. O. Kappe,
J. Pham. Biomed. Anal. 2011, 53, 867-873.

212. Microwave-Assisted and Continuous Flow Multistep Synthesis of 4-(Pyrazol-1-yl)carboxanilides.
D. Obermayer, T. N. Glasnov, C. O. Kappe,
J. Org. Chem. 2011, 76, 6657-6669.

211. Scale-Up of Microwave-assisted Reactions in a Multimode Bench-top Reactor.
D. Dallinger, H. Lehmann, J. D. Moseley, A. Stadler, C. O. Kappe,
Org. Process Res. Develop. 2011, 15, 841-854.

210. A Scalable Two-Step Continuous Flow Synthesis of Nabumetone and Related 4-Aryl-2-butanones.
M. Viviano, T. N. Glasnov, B. Reichart, G. Tekautz, C. O. Kappe
Org. Process Res. Develop. 2011, 15, 858-870.

209. Engineering of the TRPC3 Selectivity Filter Reveals a Dichotomic, TRPC-mediated
Signaling Gateway in Cardiac Excitation-transcription Coupling.
M. Poteser, H. Schleifer, M. Lichtenegger, M. Schernthaner, T. Stockner, C. O. Kappe, T. N. Glasnov, C. Romanin, K. Groschner,
Proc. Nat. Acad. Sci. USA 2011, 108, 10556-10561.

208. Activation and Deactivation of a Chemical Transformation by an Electromagnetic Field – Evidence for Specific Microwave Effects in the Formation of Grignard Reagents.
B. Gutmann, A. M. Schwan, B. Reichart, C. Gspan, F. Hofer, C. O. Kappe,
Angew. Chem. Int. Ed. 2011, 50, 7636-7640.

207. Pentafluorophenyl-bis(diethylamino)phosphane - A Push-Pull Phosphane Available for Coordination.
A. Orthaber, M. Fuchs, F. Belaj, G. N. Rechberger, C. O. Kappe, R. Pietschnig,
Eur. J. Inorg. Chem. 2011, 2588-2596.

206. Unusual Behavior in the Reactivity of 5-Substituted-1H-tetrazoles in a Resistance-Heated Microreactor.
B. Gutmann, T. N. Glasnov, T. Razzaq, W. Goessler, D. M. Roberge, C. O. Kappe,
Beilstein. J. Org. Chem. 2011, 7, 503-717.

205. Mechanistic Insights on Azide-Nitrile Cycloadditions: On the Dialkyltin Oxide-Trimethylsilyl Azide Route and a New Vilsmeier-Haack-Type Organocatalyst.
D. Cantillo, B. Gutmann, C. O. Kappe,
J. Am. Chem. Soc. 2011, 133, 4465-4475.

204. Microwave-Assisted Nickel(II) Acetylacetonate-Catalyzed Arylation of Aldehydes with Arylboronic Acids.
W. Chen, M. Baghbanzadeh, C. O. Kappe,
Tetrahedron Lett. 2011, 52, 1677-1679.

203. Continuous Flow Ozonolysis in a  Laboratory Scale Reactor.
M. Irfan, T. N. Glasnov, C. O. Kappe,
Org. Lett. 2011, 14, 984-987.

202. Rapid Nickel-Catalyzed Suzuki- Miyaura Cross-Couplings of Aryl Carbamates and Sulfamates Utilizing Microwave Heating.
M. Baghbanzadeh, C. Pilger, C. O. Kappe,
J. Org. Chem. 2011, 76, 1507-1510.

201. A Miniaturized Microtiter Plate Protocol for the Determination of Selenomethionine in Selenized Yeast via Enzymatic Hydrolysis of Protein-bound Selenium.
M. Stiboller, M. Damm, A. M. Barbera, D. Kuehnelt, K. A. Francesconi, C. O. Kappe,
Anal. Meth. 2011, 3, 738-741.
 
200. Investigation of the Formation of CuInS2 Nanoparticles by the Oleylamine Route – Comparison of Microwave-Assisted with Conventional Syntheses.
A. Pein, M. Baghbanzadeh, T. Rath, W. Haas, E. Maier, H. Amenitsch, F. Hofer, C. O. Kappe, G. Trimmel,
Inorg. Chem. 2011, 50, 193-200.

199. A Unified Mechanistic View on the Morita-Baylis-Hillman Reaction: Computational and Experimental Investigations.

D. Cantillo, C. O. Kappe,

J. Org. Chem. 2010, 75, 8615-8626.

198. Microwave-Assisted High-Throughput Acid Hydrolysis in Silicon Carbide Microtiter Platforms - A Rapid and Low Volume Sample Preparation Technique for Total Amino Acid Analysis in Proteins and Peptides.

M. Damm, M. Holzer, G. Radspieler, G. Marsche, C. O. Kappe,

J. Chromat. A. 2010, 1217, 7826-7832.

197. Toward a Continuous Flow Synthesis of Boscalid.

T. N. Glasnov, C. O. Kappe

Adv. Synth. Catal. 2010, 352, 3089-3097.

196. Structure-Activity Relationships and Molecular Docking of Novel Dihydropyrimidine-Based Mitotic Eg5 Inhibitors.

H. Prokopcová, D. Dallinger, G. Uray, H. Y. K. Kaan, V. Ulaganathan, F. Kozielski, C. Laggner, C. O. Kappe,

ChemMedChem 2010, 5, 1760-1769.

195. Sintered Silicon Carbide: A New Ceramic Vessel Material for Microwave Chemistry in Single-Mode Reactors.

B. Gutmann, D. Obermayer, B. Reichart, B. Prekodravac, M. Irfan, J. M. Kremsner, C. O. Kappe,

Chem. Eur. J. 2010, 16, 12182-1294.

194. Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles and Hydrazoic Acid Using a Safe and Scalable High-Temperature Microreactor Approach.

B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe,

Angew. Chem. Int. Ed. 2010, 49, 7101-7105.

193. An Investigation of Wall Effects in Microwave-Assisted Ring-Closing Metathesis and Cyclotrimerization Reactions.

D. Dallinger, M. Irfan, A. Suljanovic, C. O. Kappe,

J. Org. Chem. 2010, 75, 5278–5288.

192. Electromagnetic Simulations of Microwave Heating Experiments Using Reaction Vessels Made out of Silicon Carbide.

J. Robinson, S. Kingman, D. Irvine, P. Licence, A. Smith, G. Dimitrakis, D. Obermayer,

C. O. Kappe,

Phys. Chem. Chem. Phys. 2010, 12, 10793-10800.

191. Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and HPc45.

H. Y. K. Kaan, V. Ulaganathan, O. Rath, H. Prokopcová, D. Dallinger, C. O. Kappe, F. Kozielski.

J. Med. Chem. 2010, 53, 5676–5683.

190. Diversity-Oriented Synthesis of Dibenzoazocines and Dibenzoazepines via a Microwave-Assisted Intramolecular A3-Coupling Reaction.

J. B. Bariwal, D. S. Ermolat’ev, T. N. Glasnov, K. Van Hecke, V. P. Mehta, L. Van Meervelt, C. O. Kappe, E. Van der Eycken,

Org. Lett. 2010, 13, 2774–2777.

189. Understanding Microwave Heating Effects in Single Mode Type Cavities – Theory and Experiment.

J. Robinson, S. Kingman, D. Irvine, P. Licence, A. Smith, G. Dimitrakis, D. Obermayer, C. O. Kappe,

Phys. Chem. Chem. Phys. 2010, 12, 4750-4758.

188. Direct Solid-Phase Synthesis of the β-Amyloid (1-42) Peptide Using Controlled Microwave Heating.

B. Bacsa, S. Bősze, C. O. Kappe

J. Org. Chem. 2010, 75, 2103-2106.

187. Mechanistic Insights Into Copper(I)-Catalyzed Azide-Alkyne Cycloadditions Using Continuous Flow Conditions.

M. Fuchs, W. Goessler, C. Pilger, C. O. Kappe

Adv. Synth. Catal. 2010, 352, 323-328.

186. Synthesis of Poly(ε-caprolactone) Diols and and EO-CL Block Copolymers and their Characterization by Liquid Chromatography and MALDI-TOF-MS.

H. Ahmed, B. Trathnigg, C. O. Kappe, R. Saf,

Eur. Pol. J. 2010, 46, 494-505.

185. Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes.

M. Damm, T. N. Glasnov, C. O. Kappe,

Org. Process Res. Develop. 2010, 14, 215-224.

184. Microwave-assisted High-throughput Derivatization Techniques Utilizing Silicon Carbide Microtiter Platforms

M. Damm, G. Rechberger, M. Kollroser, C. O. Kappe,

J. Chromat. A. 2010, 1217, 167-170.

183. Microwave-Assisted Synthesis of 5-Arylazo-4,6-disubstituted-3-cyano-2-pyridone Dyes.

D. Z. Mijin, M. Baghbanzadeh, C. Reidlinger, C. O. Kappe

Dyes Pigments 2010, 85, 73-78.

182. On the Importance of Simultaneous Infrared/Fiber-Optic Temperature Monitoring in the Microwave-Assisted Synthesis of Ionic Liquids.

D. Obermayer, C. O. Kappe

Org. Biomol. Chem. 2010, 8, 114-121.

181. Microwave Chemistry in Silicon Carbide Reaction Vials: Separating Thermal from Nonthermal Effects.

D. Obermayer, B. Gutmann, C. O. Kappe

Angew. Chem. Int. Ed. 2009, 48, 8321-8342.

180. High-Speed Microwave-Assisted Synthesis of the Trifluoromethylpyrazol-derived Canonical Transient Receptor Potential Channel (TRPC3) Inhibitor Pyr3.

T. N. Glasnov, K. Groschner, C. O. Kappe

ChemMedChem 2009, 4, 1816-1818.

179. Microwave-Assisted Cross-Coupling and Hydrogenation Chemistry Using Heterogeneous Transition-Metal Catalysts: An Evaluation of the Role of Selective Catalyst Heating.

M. Irfan, M. Fuchs, T. N. Glasnov, C. O. Kappe

Chem. Eur. J. 2009, 15, 11608-11618.

178. Accessing Novel Process Windows in a High-Temperature/Pressure Capillary Flow Reactor.
T. Razzaq, T. N. Glasnov, C. O. Kappe,
Chem. Eng. Technol. 2009, 32, 1702-1716.

177. Kinetic Resolution of rac-1-Phenylethanol Using Immobilized Lipases – A Critical Comparison of Microwave and Conventional Heating Protocols.

R. O. M. A. de Souza, O. A. C. Antunes, W. Kroutil, C. O. Kappe,

J. Org. Chem. 2009, 74, 6157-6162.

176. Characterization of Poly(ethylene glycol)-b-poly(epsilon-caprolactone) by Liquid Chromatography under Critical Conditions: Influence of Catalysts and Reaction Conditions on Product Composition

H. Ahmed, B. Trathnigg, C. O. Kappe, R. Saf,

Eur. Pol. J. 2009, 45, 2338-2347.

175. An Evaluation of Microwave-Assisted Derivatization Procedures Using Hyphenated Mass Spectrometric Techniques.

M. Damm, G. Rechberger, M. Kollroser, C. O. Kappe,

J. Chromat. A. 2009, 1216, 5875-5881.

174. Palladium(0)-Catalyzed, Copper(I)-Mediated Coupling of Cyclic Thioamides with Alkenylboronic Acids, Organostannanes and Siloxanes.

N. Arshad, J. Hashim. C. O. Kappe

J. Org. Chem. 2009, 74, 5118-5121.

173. Parallel Microwave Chemistry in Silicon Carbide Reactor Platforms: An In-Depth Investigation Into Heating Characteristics.

M. Damm, C. O. Kappe,

Mol. Diversity 2009, 13, 529-543.

172. One-Pot Multicomponent Preparation of Tetrahydropyrazoloquinolinones and Tetrahydropyrazoloquinazolinones.

T. N. Glasnov, C. O. Kappe,

Org. Synth. 2009, 86, 252-261.

171. Parallel Microwave Synthesis of 2-Styrylquinazolin-4(3H)-ones in a High-Throughput Platform Using HPLC/GC Vials as Reaction Vessels.

M. Baghbanzadeh, M. Molnar, M. Damm, C. Reidlinger, M. Dabiri, C. O. Kappe,

J. Comb. Chem. 2009, 11, 676-684.

170. Bisquinolones as Chiral Fluorophores – A Combined Experimental and Computational Study of Absorption and Emission Characteristics

G. Uray, A.-M. Kelterer, J. Hashim, T. N. Glasnov, C. O. Kappe, W. M. F. Fabian,

J. Mol. Struct. 2009, 929, 85-96.

169. Microwave-Assisted Aliphatic Fluorine–Chlorine Exchange Using Triethylamine Trihydrofluoride (TREAT–HF).

J. M. Kremsner, M. Rack, C. Pilger, C. O. Kappe,

Tetrahedron Lett. 2009, 50, 3665-3668.

168. High-Throughput Experimentation Platform: Parallel Microwave Chemistry in HPLC/GC Vials.

M. Damm, C. O. Kappe,

J. Comb. Chem. 2009, 11, 460-468.

167. Microwave-Assisted Polymerizations of Higher Alkylene Oxides.

M. I. Malik, B. Trathnigg, C. O. Kappe

Eur. Pol. J. 2009, 45, 899-910.

166. Can Molecular Sieves Be Used as Water Scavengers in Microwave Chemistry?

M. Baghbanzadeh, C. O. Kappe

Austr. J. Chem. 2009, 62, 244-249.

165. Continuous Flow Hydrogenation of Functionalized Pyridines

M. Irfan, E. Petricci, T. N. Glasnov, M. Taddei, C. O. Kappe

Eur. J. Org. Chem. 2009, 1326-1334.

164. Continuous Flow Microreactor Chemistry Under High Temperature/Pressure Conditions.

T. Razzaq, T. N. Glasnov, C. O. Kappe

Eur. J. Org. Chem. 2009, 1321-1325.

163. Heterogeneous Versus Homogeneous Palladium Catalysts for Ligandless Mizoroki-Heck Reactions. A Comparison of Batch/Microwave and Continuous Flow Processing.

T. N. Glasnov, S. Findenig, C. O. Kappe

Chem. Eur. J. 2009, 15, 1001-1015.

162. Microwave-Assisted Carbonyl Chemistry for the Undergraduate Laboratory.

S. S. Murphree, C. O. Kappe

J. Chem. Educ. 2009, 86, 227-229.

161. Amphiphilic Polymers Based on Higher Alkylene Oxides: Synthesis and Characterization by Different Chromatographic Techniques.

M. I. Malik, B. Trathnigg, C. O. Kappe

J. Chromat. A. 2009, 1216, 1167-1173.

160. Multicomponent Cyclocondensation Reactions of Aminoazoles, Arylpyruvic Acids and Aldehydes with Controlled Chemoselectivity

Y. I. Sakhno, S. M. Desenko, S. V. Shishkina, O. V. Shishkin, D. O. Sysoyev, U. Groth, C. O. Kappe, V. A. Chebanov

Tetrahedron 2008, 64, 11041-11049.

159. Solid-Phase Synthesis of Difficult Peptide Sequences at Elevated Temperatures – A Critical Comparison of Microwave and Conventional Heating Technologies.

B. Bacsa, K. Horváti, S. Bősze, F. Andreae, C. O. Kappe

J. Org. Chem. 2008, 73, 7532-7542.

158. Investigating the Existence of Nonthermal/Specific Microwave Effects Using Silicon Carbide Heating Elements as Power Modulators.

T. Razzaq, J. M. Kremsner, C. O. Kappe

J. Org. Chem. 2008, 73, 6321-6329.

157. Microwave-Assisted One-Pot Diboration/Suzuki Cross-Couplings. A Rapid Route to Tetrasubstitued Alkenes.

H. Prokopcova, J. Ramírez, E.  Fernández, C. O. Kappe,

Tetrahedron Lett. 2008, 49, 4831-4835.

156. Tuning of Chemo- and Regioselectivities in Multicomponent Condensations of 5-Aminopyrazoles, Dimedone and Aldehydes

V. Chebanov, V. Saraev, S. Desenko, V. Chernenko, I. Knyazeva, U. Groth, T. Glasnov, C. O. Kappe

J. Org. Chem. 2008, 73, 5110-5118.

155. Synthesis of Bisquinolone-Based Mono- and Diphosphine Ligands of the Aza-BINAP Type

N. Arshad, J. Hashim. C. O. Kappe

J. Org. Chem. 2008, 73, 4755-4758.

154. Tetra-t-butyl-trioxabicyclo[3.3.1]nonadiene-dicarboxylic acid: Optical Resolution, Absolute Configuration and Application in Chiral Discrimination

J. M. Kremsner, B. C.Wallfisch, F. Belaj, G. Uray, C. O. Kappe, C. Wentrup, G. Kollenz

Eur. J. Org. Chem. 2008, 3382-3388.

153. Palladium(0) Nanoparticles on Glass-Polymer Composite Materials as Recyclable Catalysts: A Comparison Study on Their Use in Batch and Continuous Flow Processes

K. Mennecke, R. Cecilia, T. N. Glasnov, S. Gruhl, C. Vogt, A. Feldhoff, M. A. L. Vargas, C. O. Kappe, U. Kunz, A. Kirschning

Adv. Synth. Catal. 2008, 350, 717-730.

152. Integration of High Speed Microwave Chemistry and a Statistical “Design of Experiment” Approach for the Synthesis of the Mitotic Kinesin Eg5 Inhibitor Monastrol

T. N. Glasnov, H. Tye, C. O. Kappe

Tetrahedron 2008, 64, 2035-2041.

151. Microwave-Assisted Catalyst-Free Transesterification of Triglycerides with 1-Butanol under Supercritical Conditions

J. Geuens, J. M. Kremsner, B. A. Nebel, S. Schober, R. A. Dommisse, M. Mittelbach, S. Tavernier, C. O. Kappe, B. U. W. Maes

Energy Fuels 2008, 22, 643-645.

150. On the Enery Efficiency of Microwave-Assisted Organic Reactions

T. Razzaq, C. O. Kappe

ChemSusChem 2008, 1, 123-132.

149. Microwave-Assisted Synthesis and Characterization of End-Functionalized Poly(propylene oxide) as Model Compounds

M. I. Malik, B. Trathnigg, C. O. Kappe

Eur. Pol. J. 2008, 44, 144-154.

148. Nonthermal Microwave Effects Revisited – On the Importance of Internal Temperature Monitoring and Agitation in Microwave Chemistry

M. A. Herrero, J. M. Kremsner, C. O. Kappe

J. Org. Chem. 2008, 73, 36-47. 

147. Electrooxidation of Biginelli Dihydropyrimidones.

J. M. Aceves, R. Miranda, C. O. Kappe

ECS Transactions 2007, 3(32) 41-55.

146. Microwave-Assisted Click Chemistry for the Preparation of 3- and 4-Triazolyl-2(1H)-quinolones as Potential Fluorescent Probes

T. N. Glasnov, C. O. Kappe,

QSAR Comb. Sci. 2007, 26, 1261-1265.

145. Selectivity of EO-PO Diblock Copolymers in the Microwave-assisted Anionic Ring-Opening Polymerization of Propylene Oxide with PEG as Initiator.

M. I. Malik, B. Trathnigg, C. O. Kappe

Macromol. Chem. Phys. 2007, 208, 2510-2524.

144. Multicomponent Cyclocondensations of ß-Ketosulfones with Aldehydes and Aminoazole Building Blocks.

E. S. Gladkov, V. A. Chebanov, S. M. Desenko, O. V. Shishkin, S. V. Shishkina, D. Dallinger, C. O. Kappe

Heterocycles 2007, 73, 469-480.

143. Synthesis of Symmetrical Bisquinolones via Nickel(0)-Catalyzed Homocoupling of 4-Chloroquinolones.

J. Hashim, C. O. Kappe,

Adv. Synth. Catal. 2007, 349, 2353-2360.

142. Microwave Accelerated Aza-Claisen Rearrangements.

J. Gonda, M. Martinková, A. Zadrošová, M. Šoteková, J. Raschmanová, P. Čonka, E. Gajdošíková, C. O. Kappe,

Tetrahedron Lett. 2007, 48, 6912-6915.

141. Rapid Solid-Phase Synthesis of a Calmodulin-Binding Peptide Using Controlled Microwave Irradiation

B. Bacsa, C. O. Kappe,

Nat. Protoc. 2007, 2, 2222-2227.

140. Microwave-Assisted Arylation of rac-(E)-3-Acetoxy-1,3-diphenylprop-1-ene with Arylboronic acids.

V. Poláčková, Š. Toma, C. O. Kappe,

Tetrahedron 2007, 63, 8742-8745.

139. An Algorithm for the Deconvolution of Mass Spectrosopic Patterns in Isotope Labeling Studies. Evaluation for the Hydrogen-Deuterium Exchange Reaction in Ketones.

C. C. Gruber, G. Oberdorfer, C. V. Voss, J. M. Kremsner, C. O. Kappe, W. Kroutil,

J. Org. Chem. 2007, 72, 5778-5783.

138. Microwave-Assisted Selective 5´-O-Trityl Protection of Inosine Derivatives.

E. Casanova, M.-J. Pérez-Pérez, C. O. Kappe,

Synlett 2007, 1733-1735.

137. Automated Generation of a Dihydropyrimidine Compound Library Using Microwave-Assisted Processing

D. Dallinger, C. O. Kappe,

Nat. Protoc. 2007, 2, 1713-1721.

136. Palladium(0)-Catalyzed, Copper(I)-Mediated Coupling of Boronic Acids with Cyclic Thioamides. Selective Carbon-Carbon Bond Formation for the Functionalization of Heterocycles.

H. Prokopcova, C. O. Kappe,

J. Org. Chem. 2007, 72, 4440-4448.

135. Parallel Synthesis of an Amide Library Based on the 6,8-Dioxa-3-azabicyclo[3.2.1]octaneScaffold by Direct Aminolysis of Methyl Esters. 

F. Machetti, I. Bucelli, G. Indiani, C. O. Kappe, A. Guarna,

J. Comb. Chem. 2007, 9, 454-461.

134. 5-Aroyl-3,4-dihydropyrimidin-2-one Library Generation via Automated Sequential and Parallel Microwave-assisted Synthesis Techniques.

L. Pisani, H. Prokopcova, J. M. Kremsner, C. O. Kappe,

J. Comb. Chem. 2007, 9, 415-421.

133. One-Pot, Multicomponent Route to Pyrazoloquinolizines.

V. A. Chebanov, V. E. Saraev, S. M. Desenko, V. N. Chernenko, S. V. Shishkina, O. V. Shishkin, K. M. Kobzar, C. O. Kappe,

Org. Lett. 2007, 10, 1691-1694.

132. Rapid Preparation of Pyranoquinolines using Microwave Dielectric Heating in Combination with Fractional Product Distillation.

T. Razzaq, C. O. Kappe,

Tetrahedron Lett. 2007, 48, 2513-2517.

131. High-Throughput Microwave-Assisted Organic Synthesis - Moving from Automated Sequential to Parallel Library Generation Formats in Silicon Carbide Microtiter Plates.

J. M. Kremsner, A. Stadler, C. O. Kappe,

J. Comb. Chem. 2007, 9, 285-291.

130. Microwave-Assisted Solution- and Solid-Phase Synthesis of 2-Amino-4-arylpyrimidine Derivatives.

M. Matloobi, C. O. Kappe,

J. Comb. Chem. 2007, 9, 275-284.

129. Rapid Preparation of the Mitotic Kinesin Eg5 Inhibitor Monastrol Using Controlled Microwave-Assisted Synthesis.

D. Dallinger, C. O. Kappe,

Nat. Protoc. 2007, 2, 317-321.

128. Microwave-Assisted Asymmetric Organocatalysis. A Probe for Non-Thermal Microwave Effects and the Concept of Simultaneous Cooling.

M. Hosseini, N. Stiasni, V. Barbieri, C. O. Kappe,

J. Org. Chem. 2007, 72, 1417-1424.

127. Desulfitative Carbon–Carbon Cross-Coupling of Thioamide Fragments with Boronic Acids.

H. Prokopcova, C. O. Kappe,

Adv. Synth. Catal. 2007, 349, 448-452.

126. Cyclocondensation Reactions of 5-Aminopyrazoles, Pyruvic Acids and Aldehydes. Multicomponent Approaches to Pyrazolopyridines and Related Products.

V. A. Chebanov, Y. I. Sakhno, S. M. Desenko, V. N. Chernenko, V. I. Musatov, S. V. Shishkina, O. V. Shishkin, C. O. Kappe,

Tetrahedron 2007, 63, 1229-1242.

125. Synthesis of 5-Aroyl-dihydropyrimidinones via Liebeskind-Srogl Thiol Ester-Boronic Acid Cross Couplings.

H. Prokopcova, L. Pisani, C. O. Kappe,

Synlett 2007, 43-46. 

124. Rapid Solid-Phase Peptide Synthesis using Thermal and Controlled Microwave Irradiation.

B. Bacsa, B. Desai, G. Dibo, C. O. Kappe,

J. Pept. Sci. 2006, 12, 633-638.

123. Silicon Carbide Passive Heating Elements in Microwave-Assisted Organic Synthesis.

J. M. Kremsner, C. O. Kappe,

J. Org. Chem. 2006, 71, 4651-4658.

122. Microwave-Assisted Three-Component Synthesis of 7-Aryl-2-alkylthio-4,7-dihydro-1,2,4-triazolo[1,5-a]-pyrimidine-6-carboxamides and Their Selective Reduction.

 V. A. Chebanov, E. A. Muravyova, S. M. Desenko, V. I. Musatov, I. V. Knyazeva, S. V. Shishkina, O. V. Shishkin, C. O. Kappe,

J. Comb. Chem. 2006, 8, 427-434.

121. Microwave-Assisted Dimroth Rearrangement of Thiazines to Dihydropyrimidinethiones: Synthetic and Mechanistic Aspects.

T. N. Glasnov, D. J. Vugts, M. M. Koningstein, B. Desai, W. M. F. Fabian, R. V. A. Orru, C. O. Kappe,

QSAR Comb. Sci. 2006, 25, 509-518.

120. Microwave-Assisted Solution Phase Synthesis of Dihydropyrimidine C5 Amides and Esters.

B. Desai, D. Dallinger, C. O. Kappe,

Tetrahedron 2006, 62, 4651-4664.

119. Symmetrical Bisquinolones via Metal-Catalyzed Cross-Coupling and Homocoupling Reactions.

J. Hashim, T. N. Glasnov, J. M. Kremsner, C. O. Kappe,

J. Org. Chem. 2006, 71, 1707-1710. 

118. Heterogeneous Hydrogenation Reactions Using a Continuous Flow High Pressure Device.

B. Desai, C. O. Kappe,

J. Comb. Chem. 2005, 7, 641-643.

117. Monolithic Polymer/Carrier Materials: Versatile Composites for Fine Chemical Synthesis.

U. Kunz, A. Kirschning, H.-L. Wen, W. Solodenko, R. Cecilia, C. O. Kappe, T. Turek,

Catal. Today 2005, 105, 318-324.

116. Microwave-Assisted Organic Synthesis in Near-Critical Water at 300 °C. A Proof-of-Concept Study.

J. M. Kremsner, C. O. Kappe,

Eur. J. Org. Chem. 2005, 3672-3679.

115. Porphyrins in Diels-Alder Reactions. Improvements on the Synthesis of Barrelene-fused Chlorins using Microwave Irradiation.

A. M. G. Silva, A. C. Tomé, M. G. P. M. S. Neves, J. A. S. Cavaleiro, C. O. Kappe,

Tetrahedron Lett. 2005, 46, 4723-4726.

114. Novel Microwave-Enhanced and Metal-Catalyzed Functionalizations of the 4-Aryl-Dihydropyrimidone Template.

J. Wannberg, D. Dallinger, C. O. Kappe, M. Larhed,

J. Comb. Chem. 2005, 7, 574-583.

113. The Application of “Click Chemistry” for the decoration of the 2(1H)-Pyrazinone Scaffold: Generation of New Interesting Templates.

N. Kaval, D. Ermolat’ev, P. Appukkuttan, W. Dehaen, C. O. Kappe, E. Van der Eycken,

J. Comb. Chem. 2005, 7, 490-502.

112. Microwave-Assisted Multistep Synthesis of Functionalized 4-Arylquinolin-2(1H)-ones using Palladium-Catalyzed Cross-Coupling Chemistry.

T. N. Glasnov, W. Stadlbauer, C. O. Kappe,

J. Org. Chem. 2005, 70, 3864-3870.

111. Selective Polymer-Assisted Product Sequestration for the Generation of Combinatorial Libraries of 1,3-Thiazines.

G. A. Strohmeier, C. Reidlinger, C. O. Kappe,

QSAR Comb. Sci. 2005, 24, 364-377. 

110. Combining Biginelli Multicomponent and Click Chemistry: Generation of 6-(1,2,3-Triazol-1-yl)-Dihydropyrimidone Libraries.

B. Khanetskyy, D. Dallinger, C. O. Kappe,

J. Comb. Chem. 2004, 6, 884-892.

109. Stereoconservative Negishi Arylation and Alkynylation as an Efficient Approach to Enantiopure 2,2’-Diarylated 1,1’-Binaphthyls.

K. Krascsenicsováa, P. Walla, P. Kasáka, G. Uray, C. O. Kappe, M. Putala,

Chem. Commun. 2004, 2606-2607.

108. A Diversity-Oriented, Microwave-Assisted Synthesis of  4-oxo and 4-chloropyrido[2,3-d]pyrimidin-7(8H)-ones.

N. Mont, L. Fernández-Megido, J. Teixidó, C. O. Kappe , J. I. Borrell,

QSAR Comb. Sci. 2004, 23, 836-849.

107. Synthesis of Functionalized 1,3-Thiazine Libraries Combining Solid-Phase Synthesis and Post-Cleavage Modification Methods.

G. A. Strohmeier, W. Haas, C. O. Kappe,

Chem. Eur. J. 2004, 10, 2919-2926.

106. Rapid Microwave-Assisted Solution Phase Synthesis of Substituted 2-Pyridone Libraries.

N. Yu. Gorobets, B. H. Yousefi, F. Belaj, C. O. Kappe,

Tetrahedron 2004, 60, 8633-8644.

105. 2,6,9-Trioxabicyclo[3.3.1]nona-3,7-dien-4-oyl and Tetraoxaadamantan-9-oyl Functionalized Aromatic Di- and Triamines: Synthesis, Stereochemistry and Complexation.

W. Heilmayer, R. Smounig, K. Gruber, W. M. F. Fabian, C. Reidlinger, C. O. Kappe, C. Wentrup, G. Kollenz,

Tetrahedron 2004, 60, 2857-2867

104. Tunable Carbon-Carbon and Carbon-Sulfur Cross-Coupling of Boronic Acids with 3,4-Dihydropyrimidine-2-thiones.

A. Lengar, C. O. Kappe,

Org. Lett. 2004, 6, 771-774.

103. Microwave-Assisted Negishi and Kumada Cross-Coupling Reactions of Aryl Chlorides.

P. Walla, C. O. Kappe,

Chem. Commun. 2004, 564-565.

102. Combinatorial Synthesis of Functionalized 1,3-Thiazine Libraries Using a Combined Polymer-Supported Reagent/Catch-and-Release Strategy.

G. A. Strohmeier, C. O. Kappe,

Angew. Chem. Int. Ed. 2004, 43, 621-624.

101. The effect of pressure on microwave-enhanced Diels–Alder reactions. A case study.

N. Kaval , W. Dehaen , C. O. Kappe, E. Van der Eycken,

Org. Biomol. Chem. 2004, 2, 154-156

100. Novel Macrocyclic Systems containing 2,6,9-Trioxabicyclo[3.3.1]nona-3,7-dienes as Chiral Spacer Groups : Synthesis, Stereochemical Features and Preliminary Complexation Properties.

V. A.Chebanov, C. Reidlinger, H. Kanaani, C. Wentrup, C. O. Kappe, G. Kollenz,

Supramol. Chem. 2004, 16, 121-127.

99. Microwave-Assisted Scavenging of Electrophiles Utilizing Polymer-Supported Sequestration Reagents. Application to the Synthesis of N3-Acylated Dihydropyrimidine Libraries.

D. Dallinger, N. Yu. Gorobets, C. O. Kappe,

Mol. Diversity 2003, 7, 229-245.

98. A One-Pot Microwave-Assisted Synthesis of Pyrido[2,3-d]pyrimidines.

N. Mont, J. Teixidó, C. O. Kappe, J. I. Borrell,

Mol. Diversity 2003, 7, 153-159.

97. Microwave-Enhanced Transition Metal-Catalyzed Decoration of  2(1H)-Pyrazinone Scaffolds.

N. Kaval, K. Bisztray, W. Dehaen, C. O. Kappe, E. Van der Eycken,

Mol. Diversity 2003, 7, 125-133.

96. Microwave-Assisted Ring-Closing Metathesis Revisited. On the Question of the Non-Thermal Microwave Effect.

S. Garbacia, B. Desai, O. Lavastre, C. O. Kappe,

J. Org. Chem. 2003, 68, 9136-9139.

95. Scalability of Microwave-Assisted Organic Synthesis. From Single-Mode to Multimode Parallel Batch Reactors.

A. Stadler, B. H. Yousefi, D. Dallinger, P. Walla, E. Van der Eycken, N. Kaval, C. O. Kappe

Org. Process Res. Dev. 2003, 7, 707-716.

94. Synthesis and Host-Abilities of some new Corands Bearing Uncommon Chiral Spacer Units.

W. Heilmayer, B. Wallfisch, C. O. Kappe, C. Wentrup, K. Gloe, G. Kollenz,

Supramol. Chem. 2003, 15, 375-383.

93. An Exploratory Study on Microwave-Assisted Solid-Phase Diels-Alder Reactions of 2(1H)-Pyrazinones: The Elaboration of a New Tailor-Made Acid-Labile Linker.

 N. Kaval, J. Van der Eycken, J. Caroen, W. Dehaen, G. A. Strohmeier, C. O. Kappe, E. Van der Eycken,

 J. Comb. Chem. 2003, 5, 560-568.

92. A Three-Component Synthesis of Pyrido[2,3-d]pyrimidines.

N. Mont, J. Teixidó, J. I. Borrell, C. O. Kappe,

Tetrahedron Lett. 2003, 44, 5385-5387.

91. Synthesis and Complexation Properties of Some Novel Lariat-Crown Ethers.

R. Smounig, C. O. Kappe, C. Wentrup, G. Kollenz,

Monatsh. Chem. 2003, 134, 509-518.

90. Enantioseparation of Racemic 4-Aryl-3,4-dihydro-2(1H)-pyrimidones on Chiral Stationary Phases Based on 3,5-Dimethylanilides of N-(4-Alkylamino-3,5-dinitro)benzoyl L-a-Amino Acids.

D. Kontrec, V. Vinkovic, V. Sunjic, B. Schuiki, W. M. F. Fabian, C. O. Kappe,

Chirality 2003, 15, 550-557.

89. High-Throughput Synthesis of N3-Acylated Dihydropyrimidines Combining Microwave-Assisted Synthesis and Scavenging Techniques.

D. Dallinger, N. Yu. Gorobets, C. O. Kappe.

Org. Lett. 2003, 5, 1205-1208.

88. Rapid Preparation of Thioamide Building Blocks via Microwave-Promoted Three-Component Kindler Reactions.

O. I. Zbruyev, N. Stiasni, C. O. Kappe,

J. Comb. Chem. 2003, 5, 145-148. 

87. High-Speed Microwave-Promoted Hetero-Diels-Alder Reactions of 2(1 H)-Pyrazinones in Ionic Liquid Doped Solvents.

E. Van der Eycken, P. Appukkuttan, W. De Borggraeve, W. Dehaen, D.Dallinger, C. O. Kappe,

J. Org. Chem. 2002, 67, 7904-7907.

86. Selective N 1-Alkylationof 3,4-Dihydropyrimidin-2(1H)-ones Using Mitsunobu-Type Conditions.

D. Dallinger, C. O. Kappe,

Synlett 2002, 1901-1903.

85. Rapid Formation of Triarylphosphines by Microwave-Assisted Transition Metal-Catalyzed C-P Cross-Coupling Reactions.

A. Stadler, C. O. Kappe,

Org. Lett. 2002, 4, 3541-3543.

84. A Tandem Intramolecular Michael-Addition/Elimination Sequence in Dihydropyrimidone to Quinoline Rearrangements.

N. Stiasni, C. O. Kappe,

ARKIVOC 2002, (8), 71-79.

83. Traceless Solid Phase Synthesis of Bicyclic Dihydropyrimidones Using Multidirectional Cyclization Cleavage.

R. Pérez, T. Beryozkina, O. I. Zbruyev, W. Haas. C. O. Kappe,

J. Comb. Chem. 2002, 4, 501-510.

82.2,6,9-Trioxabicyclo[3.3.1]nona-3,7-dienes and  2,4,6,8-Tetraoxaadamantanes: Novel Chiral Spacer Units in  Macrocyclic Polyethers.

B. C. Wallfisch, T. Egger,  W.Heilmayer, C. O. Kappe, C.Wentrup, K. Gloe, F. Belaj, G. Klintschar, G.  Kollenz,

Supramol. Chem. 2002, 14, 383-396.

81. Microwave-Assisted Reactions under Open and Closed Vessel Conditions.  A Case Study.

A. Stadler, S. Pichler, G. Horeis, C. O. Kappe,

Tetrahedron 2002, 58, 3177-3183.

80. Synthesis and Chemical Reactivity of  Methoxycarbonyl-1,3-dioxinyl-pivaloyketene; a Persistent a-Oxoketene.

B. C. Wallfisch, F. Belaj, C. O. Kappe, G.  Kollenz,

J. Chem. Soc., Perkin Trans. 1 2002, 599-605.

79.Rapid Parallel Synthesis of Polymer-Bound Enones Utilizing Microwave-Assisted Solid-Phase Chemistry.

G. A. Strohmeier, C. O. Kappe,

J. Comb. Chem. 2002, 4, 154-161.

78. Automated Library Generation Using Sequential Microwave-Assisted Chemistry. Application Toward the Biginelli Multicomponent Condensation.

A. Stadler, C. O. Kappe,

J. Comb. Chem. 2001, 3, 624-630.

77. Absolute Configuration in 4-Alkyl- and 4-Aryl-3,4-dihydro-2(1H)-pyrimidones: A Combined Theoretical and Experimental Investigation.

G. Uray, P. Verdino, F. Belaj, C. O. Kappe, W. M. F. Fabian,

J. Org. Chem. 2001, 66, 6685-6694.

76. Fluorocontaining 1,3-Dicarbonyl Compounds in the Synthesis of Pyrimidine Derivatives.

Y. V. Burgart, O. G. Kuzueva, M. V. Pryadeina, C. O. Kappe, Y. I. Saloutin,

Russ. J. Org. Chem. 2001, 37, 869-880.

75. On the Reaction of 3,4-Dihydropyrimidones with Nitric Acid. Preparation and X-Ray Structure Analysis of a Stable Nitrolic Acid.

A. Puchala, F. Belaj, J. Bergman, C. O. Kappe,

J. Heterocyclic Chem. 2001, 38, 1345-1352.

74. Reactions of Dipivaloylketene and its Dimer with NH2 Nucleophiles. Formation of Amides, Hydrazides, Ureides and Pyrimidine-2,4-diones.

G. Kollenz, C. O. Kappe, T.S. Dalvi, C. Wentrup,

ARKIVOC, 2001, 2, 30-41.

73. High-Speed Microwave-Promoted Mitsunobu Inversions. Application to the Deracemization of Sulcatol.

A. Steinreiber, A. Stadler, S. F. Mayer, K. Faber, C. O. Kappe,

Tetrahedron Lett., 2001, 42, 6283-6286.

72. Chiral Separation of Pharmacologically Active Dihydropyrimidinones with Carboxymethyl-ß-cyclodextrin.

O. Lecnik, M. G. Schmid, C. O. Kappe, G. Gübitz,

Electrophoresis, 2001, 22, 3198-3202.

71. Solid-Phase Synthesis of Dihydropyrimidones via N-Acyliminium Ion-Based  a-Ureidoalkylations.

M. G. Valverde, D. Dallinger, C. O. Kappe,

Synlett, 2001, 741-744.

70. The Biginelli Dihydropyrimidone Synthesis Using Polyphosphate Ester as a Mild and Efficient Cyclocondensation/Dehydration Reagent.

F. S. Falsone, C. O. Kappe,

ARKIVOC, 2001, 2, 1234-1249.

69. The Effect of Microwave Irradiation on Carbodiimide-Mediated Esterifications on Solid-Support.

A. Stadler, C. O. Kappe,

Tetrahedron, 2001, 57, 3915-3920.

68. Iminopropadienethiones, Ar-N=C=C=C=S.

C. O. Kappe, D. Kvaskoff, D. W. J. Moloney, R. Flammang, C. Wentrup,

J. Org. Chem. 2001, 66, 1827-1831.

67. Preparation and Chemistry of an Unexpectedly Stable a-Oxoketene-Pyridine Zwitterion, Di-t-butylcarbonyl-(4-dimethylamino)pyridinium Methylidene Olate.

G. Kollenz, S. Holzer, C. O. Kappe, T. S. Dalvi, W. M. F. Fabian, H.Sterk, M. W. Wong, C. Wentrup,

Eur. J. Org. Chem., 2001, 1315-1322.

66. High-Speed Couplings and Cleavages in Microwave-Heated, Solid-Phase Reactions at High Temperatures.

A. Stadler, C. O. Kappe,

Eur. J. Org. Chem. 2001, 919-925.

65. Microwave-Mediated Regioselective Synthesis of Novel Pyrimido[1,2-a]pyrimidines under Solvent-free Conditions.

J. J. Vanden Eynde, N. Hecq, O. Kataeva,  C. O. Kappe,

Tetrahedron, 2001, 57, 1785-1791. 

64. Chemoenzymatic Syntheses of Enantiomerically Pure 4-Aryl-3,4-Dihydropyrimidin-2(1H)-Ones.

B. Schnell, W. Krenn, K. Faber, C. O. Kappe,

J. Chem. Soc., Perkin Trans. 1, 2000, 4382-4389.

63. The Rhodium(II)-Catalyzed Equilibration of Push-Pull Carbonyl and Ammonium Ylides. A Computationally- Based Understanding of the Reaction Pathway.

A. Padwa, J. P. Snyder, E. A. Curtis, S. M. Sheehan, K. J. Worsencroft,C. O. Kappe,

J. Am. Chem. Soc. 2000, 122, 8155-8167.

62. Microwave-Mediated Biginelli Reactions Revisited. On the Nature of Rate and Yield Enhancements.

A. Stadler, C. O. Kappe,

J. Chem. Soc., Perkin Trans. 2, 2000, 1363-1368.

61. Design and Synthesis of a ConformationallyRigid Mimic of the  Dihydropyrimidine Calcium Channel Modulator SQ32,926.

B. Jauk, T. Pernat, C. O. Kappe,

Molecules, 2000, 5, 227-239.

60. Synthesis of Enantiomerically Pure 4-Aryl-3,4-dihydropyrimidin-2(1H)-ones via Enzymatic Resolution. Preparation of the Antihypertensive Agent (R)-SQ32926.

B. Schnell, U. T. Strauss, P. Verdino, K. Faber, C. O. Kappe,

Tetrahedron: Asymmetry, 2000, 11, 1449-1453.

59. X-Ray Structure, Conformational Analysis, Enantioseparation, and Determination of Absolute Configuration of the Mitotic Kinesin Eg5Inhibitor Monastrol.

C. O. Kappe, O. V. Shishkin, G. Uray, P. Verdino,

Tetrahedron, 2000, 56, 1859-1862.

58. Reactions of Dipivaloylketene and its Dimer with C-Nucleophiles.

G. Kollenz, T. S. Dalvi, C. O. Kappe, C. Wentrup,

ARKIVOC 2000, 1, 84-89.

57. Biginelli Condensations of Fluorinated 3-OxoEsters and 1,3-Diketones.

V. I. Saloutin, Ya. V. Burgart, O. G. Kuzueva, C. O. Kappe, O. N. Chupakhin,

J. Fluorine Chem., 2000, 103, 17-23.

56. Ab Initio and Density Functional Calculations on the Pericyclic versus Pseudopericyclic Mode of Conjugated  Nitril Ylide 1,5-Electrocyclizations.

W. M. F. Fabian, C. O. Kappe, V. A. Bakulev,

J. Org. Chem., 2000, 65, 47-53.

55. Highly Versatile Solid Phase Synthesis of Biofunctional 4-Aryl-3,4 dihydropyrimidines using Polymer-Bound Isothiourea BuildingBlocks and Multidirectional Resin Cleavage.

C. O. Kappe,

Bioorg. Med. Chem. Lett., 2000, 10, 49-51. 

54. Microwave-Assisted High-Speed Parallel Synthesis of 4-Aryl-3,4-dihydropyrimidin-2(1H)-ones using a Solventless BiginelliCondensation Protocol.

C. O. Kappe, D. Kumar, R. S. Varma,

Synthesis, 1999, 1799-1803.

53. Determination of Absolute Configuration in4-Aryl-3,4-dihydro-2(1H)-pyrimidones by High Performance Liquid Chromatographyand CD Spectroscopy.

W. Krenn, P. Verdino, G. Uray, K. Faber, C. O. Kappe,

Chirality, 1999, 11, 659-662.

52. A Rhodium-Induced Cyclization-Cycloaddition Sequence for the Construction of Conformationally Rigid Calcium ChannelModulators of the Dihydropyrimidine Type.

B. Jauk, F. Belaj, C. O. Kappe,

J. Chem. Soc., Perkin Trans. 1, 1999, 307-314.

51. Isolation, Conformational Analysis and X-RayStructure Determination of a Trifluoromethyl-Stabilized Hexahydropyrimidine- An Intermediate in the Biginelli Reaction.

C. O. Kappe, S. F. Falsone, W. M. F. Fabian, F. Belaj,

Heterocycles, 1999, 51, 77-84. 

50. Pericyclic Versus Pseudopericyclic 1,5-Electrocyclization of Iminodiazomethanes. An Ab Initio and Density Functional Theory Study.

W. M. F. Fabian, V. A. Bakulev, C. O. Kappe,

J. Org. Chem., 1998, 63, 5801-5805.

49.Synthesis and Reactions of Biginelli Compounds, 12. Polyphosphate Ester-Mediated Synthesis of Dihydropyrimidines. Improved Conditions for the Biginelli Reaction.

C. O. Kappe, S. F. Falsone,

Synlett, 1998, 718-720.

48. On the Reaction of Dipivaloylketene Dimer with Oximes and Hydrazines - Synthesis of Tetraoxaadamantanes.

T. S. Dalvi, C. O. Kappe, C. Wentup, G. Kollenz,

Heterocycles, 1998, 48, 1841-1850.

47. Synthesis and Reactions of Biginelli Compounds, 11. Ring Conformation and Ester Orientation in Dihydropyrimidinecarboxylates: A Combined Theoretical (Ab Initio, Density Functional) and X-Ray Crystallographic Study.

W. M. F. Fabian, M. A. Semones, C. O. Kappe,

J. Mol. Struct. (Theochem), 1998, 432, 219-229.

46. Carboxy(vinyl)ketene Intermediates in the Thermolysis of Methylthio- and Methoxy-Substituted Meldrum's Acid Derivatives.

H. Bibas, C. O. Kappe, M. W. Wong, C. Wentrup,

J. Chem. Soc., Perkin Trans. 2, 1998, 493-498.

45. A Triple Cascade Sequence as a Strategy for the Construction of the Erythrina Skeleton.

A. Padwa, R. Hennig, C. O. Kappe, T. S. Reger,

J. Org. Chem., 1998, 63, 1144-1155. 

44. Synthesis and Reactions of Biginelli Compunds, 9. A Reexamination of the Mechanism of the Biginelli Dihydropyrimidine Synthesis. Support for an N-Acyliminium Ion Intermediate.

C. O. Kappe,

J. Org. Chem., 1997, 62, 7201-7204.

43. Synthesis and Reactions of Biginelli Compunds, 10. Synthesis and Aromatization of Dihydropyrimidines Structurally related to Calcium Channel Modulators of the Nifedipine-Type.

J. J. Vanden Eynde, N. Audiart, V. Canonne, S. Michel, Y. Van Haverbeke, C. O. Kappe

Heterocycles, 1997, 45, 1967-1978.

42. Synthesis and Reactions of Biginelli Compunds, 8. Separation of Enantiomers of 4-Aryldihydropyrimidines by Direct Enantioselective HPLC. A Critical Comparison of Chiral Stationary Phases.

O. P. Kleidernigg, C. O. Kappe,

Tetrahedron: Asymmetry, 1997, 8, 2057-2067.

41. Ammonium Ylide Versus Carbonyl Ylide Formation in the Rhodium(II)-Catalyzed Decomposition of Diazoacetylureas. Generation and X-Ray Structure of a Stable Five-Membered N-Acyl Ammonium Ylide.

C. O. Kappe,

Tetrahedron Lett., 1997, 38, 3323-3326.

40. Synthesis and Reactions of Biginelli Compounds, 7. Dipolar Cycloaddition Reactions of Dihydropyrimidine-Fused Mesomeric Betaines. An Approach Towards Conformationally Restricted Dihydropyrimidine Derivatives.

C. O. Kappe, K. Peters, E.-M. Peters,

J. Org. Chem., 1997, 62, 3109-3118.

39. Studies Dealing with the Cycloaddition/Ring Opening/Elimination Sequence of 2-Amino-Substituted Isobenzofurans

A. Padwa, C. O. Kappe, J. E Cochran, J. P. Snyder,

J. Org. Chem., 1997, 62, 2786-2797.

38. Synthesis and Reactions of Biginelli Compounds, 6. Conformational Analysis of 4-Aryl-Dihydropyrimidine Calcium Channel Modulators. A Comparison of Ab Initio, Semiempirical and X-Ray Crystallographic Studies.

C. O. Kappe, W. M. F. Fabian, M. A. Semones,

Tetrahedron, 1997, 53, 2803-2816. 

37. A Facile and Efficient Synthesis of Thieno[2,3-c]furans and Furo[3,4-b]indoles Via a Pummerer Induced Cyclization Reaction.

C. O. Kappe, A. Padwa,

J. Org. Chem., 1996, 61, 6166-6174.

36. Tandem Diels-Alder N-Acyliminium Ion Cyclization Reactions. A New Entry into the Erythrinane Skeleton.

A. Padwa, C. O. Kappe, T. S. Reger,

J. Org. Chem., 1996, 61, 4888-4889.

35. The Tandem Pummerer Diels-Alder Reaction Sequence. A Novel Cascade Process for the Preparation of 1-Arylnaphthalene Lignans.

A. Padwa, J. E. Cochran, C. O. Kappe,

J. Org. Chem., 1996, 61, 3706-3714. 

34. Generation and Subsequent Cycloaddition Chemistry of alpha-Amino Isobenzofurans Formed by Cationic Cyclization.

C. O. Kappe, J. E. Cochran, A. Padwa,

Tetrahedron Lett., 1995, 36, 9285-9288.

33. A Convenient De Novo Synthesis of Functionalized 2,4,6,8-Tetraoxaadamantanes.

W. Heilmayer, T. S. Dalvi, C. O. Kappe, C. Wentrup, K. Gruber, H. Sterk, G. Kollenz,

J. Chem. Soc., Chem. Commun., 1995, 797-798.

32. Acetylketene: Conformational Isomerism and Photochemistry. Matrix Isolation Infrared and Ab Initio Studies.

C. O. Kappe, M. W. Wong, C. Wentrup,

J. Org. Chem., 1995, 60, 1686-1695.

31. Substituent Effects on the Site of Nucleophilic Attack in Pyrrole-2,3-diones.

C. O. Kappe, E. Terpetschnig, G. Penn, G. Kollenz, K. Peters, E.-M. Peters, H. G. von Schnering,

Liebigs Ann. Chem., 1995, 537-543. 

30. An Improved Synthesis of 5-Alkyl-2,3-dihydrofuran-2,3-diones.

C. O. Kappe, G. Kollenz, C. Wentrup,

Heterocycles, 1994, 38, 779-784.

29. Synthesis and Flash Vacuum Pyrolysis of Isoxazolo- and Isothiazolo[5,4-d]pyrimidines.

C. O. Kappe, R. Flammang, C. Wentrup,

Heterocycles, 1994, 37, 1615-1622.

28. Iminoethenethiones, RN=C=C=S: Characterization by Neutralization-Reionization Mass Spectrometry and G2(MP2) Theory.

R. Flammang, D. Landu, S. Laurent, M. Barbieux-Flammang, C. O. Kappe, M. W. Wong, C. Wentrup,

J. Am. Chem. Soc., 1994, 116, 2005-2015.

27. Conformation and Reactivity of alpha-Oxo Ketenes: Ab Initio and Semiempirical (AM1, PM3) Calculations.

R. Janoschek, W. M. F. Fabian, G. Kollenz, C. O. Kappe,

J. Comput. Chem., 1994, 15, 132-143.

26. Thioacylthioketenes by Pyrolysis of 1,3-Dithiethanes and 1,2-Dithiole Derivatives.

C. O. Kappe, C. T. Pedersen, J.-M. Catel, Y. Mollier,

J. Chem. Soc., Perkin Trans. 2, 1994, 351-355.

25. The Formation of Thioacylthioketenes by Flash Vacuum Pyrolysis of 1,2-Dithiole Derivatives.

C. T. Pedersen, C. O. Kappe,

Phosphorus, Sulfur Silicon Relat. Elem. 1994, 95-96, 485-486. 

24. [2+4] Cycloaddition Reactions of Neat Dipivaloylketene.

C. O. Kappe, C. Wentrup, G. Kollenz,

Monatsh. Chem., 1993, 124, 1331-1341.

23. Matrix Isolation and Infrared Spectrum of Thioformyl Cyanide.

C. O. Kappe, M. W. Wong, C. Wentrup,

Tetrahedron Lett., 1993, 34, 6623-6626.

22. On the Thermal Fragmentation of 3-Methyl-1-phenylpyrazole-4,5-dione.

C. O. Kappe, G. Kollenz, C. Wentrup,

Acta Chem. Scand., 1993, 47, 940-942.

21. Direct Observation and Trapping of a Heterocyclic alpha-Oxo Ketene: 3-Carbonyl-1,3-dihydro-1- methyl-2-indol-2-one.

C. O. Kappe, G. Färber, C. Wentrup, T. Kappe,

Chem. Ber., 1993, 126, 2357-2360.

20. On the Reaction of 4-Benzoyl-5-phenylfuran-2,3-dione with S-Heterocumulenes - Preparative and Mechanistic Aspects.

W. Heilmayer, C. O. Kappe, H. Sterk, G. Kollenz, K. Peters, E.-M. Peters, H.-G. von Schnering, L. Walz,

Chem. Ber., 1993, 126, 2061-2067.

19. Reactions of Dipivaloylketene-Dimer with Nucleophiles: New Access to the 2,6,9-Trioxabicyclo[3.3.1]nona-3,7-diene Ring System (Bridged Bis-Dioxines).

C. O. Kappe, G. Kollenz, W. M. F. Fabian, C. Wentrup, G. Färber,

J. Org. Chem., 1993, 58, 3361-3367. 

18. Dipivaloylketene and Its Dimers. [2+4] Versus [2+2] Cycloaddition Reactions of alpha-Oxo Ketenes.

C. O. Kappe, G. Färber, C. Wentrup, G. Kollenz, 

J. Org. Chem., 1992, 57, 7078-7083.

17. A Novel and Convenient Approach to Functionalized 2,6,9-Trioxabicyclo[3.3.1]nona-3,7-dienes (Bridged Bis-Dioxines).

C. O. Kappe, G. Färber, C. Wentrup, G. Kollenz,

Tetrahedron Lett., 1992, 33, 4553-4556.

16. Synthesis and Reactions of Biginelli Compounds, 5. Facile Preparation and Resolution of a Stable 5-Dihydropyrimidinecarboxylic Acid.

C. O. Kappe, G. Uray, P. Roschger, W. Lindner, C. Kratky, W. Keller,

Tetrahedron, 1992, 48, 5473-5480.

15. Direct Observations of Benzoylketenes.

Yu. S. Andreichikov, G. Kollenz, C. O. Kappe, R. Leung-Toung, C. Wentrup,

Acta Chem. Scand., 1992, 46, 683-685.

14. Iminopropadienones, RN=C=C=C=O: Syntheses and Reactions.

T. Mosandl, C. O. Kappe, R. Flammang, C. Wentrup,

J. Chem. Soc., Chem. Commun., 1992, 1571-1573.

13. Imidoylketene-Azetin-2-one-Oxoketenimine Rearrangement.

C. O. Kappe, G. Kollenz, K.-P. Netsch, R. Leung-Toung, C. Wentrup,

J. Chem. Soc., Chem. Commun., 1992, 488-490.

12. Methyleneketene-Imidoylketene-Oxoketenimine Rearrangements.

C. O. Kappe, G. Kollenz, R. Leung-Toung, C. Wentrup,

J. Chem. Soc., Chem. Commun., 1992, 487-488.

11. A Nitroketene to Nitrile Oxide Transformation.

C. O. Kappe, G. Kollenz, C. Wentrup,

J. Chem. Soc., Chem. Commun., 1992, 485-486. 

10. Dipivaloylketene and Its Unusual Dimerization to a Permanently Stable alpha-Oxoketene.

C. O. Kappe, R. A. Evans, C. H. L. Kennard, C. Wentrup,

J. Am. Chem. Soc., 1991, 113, 4234-4237.

9. Cross-Conjugated and Pseudo-Cross-Conjugated Mesomeric Betaines, 18. Bicyclic Mesoionic Pyrimidines with Cardiovascular Activity.

C. O. Kappe, T. Kappe,

Arch. Pharm., 1991, 324, 863-866.

8. Thermolysis and Photolysis of 6-Diazidomethyl-1,2,3,4-tetrahydro-2-oxopyrimidine-5-carboxylates (Synthesis and Reactions of Biginelli Compounds, 4).

C. O. Kappe, G. Färber,

J. Chem. Soc., Perkin Trans. 1, 1991, 1342-1344.

7. On the Reaction of 2,2,6,6,-Tetramethyl-3,5-heptanedione ("Dipivaloylmethane") with Oxalyl Chloride.

G. Kollenz, C. O. Kappe, H. Abd el Nabey,

Heterocycles, 1991, 32, 669-673. 

6. Synthesis and Reactions of Biginelli Compounds, 3. Unexpected Formation of Nitriles from Reactions of 6-(Dibromomethyl)-1,2,3,4-tetrahydro2-oxo-5-pyrimidinecarboxylates with Sodium Azide.

C. O. Kappe,

Liebigs Ann. Chem., 1990, 505-507

5. Quinolizines and Indolizines, 16. Synthesis of Pyrrolo[3,2,1-ij]quinolin-4-ones with Potential Fungicidal Activity.

C. O. Kappe, T. Kappe,

J. Heterocycl. Chem., 1989, 26, 1555-1560.  

4. Synthesis of Substituted 3-Pyridinecarbonitriles with Potential Biological Activity.

C. O. Kappe, T. Kappe,

Monatsh. Chem., 1989, 120, 1095-1100.  

3. Synthesis and Reactions of Biginelli Compounds, 2. Nitration of 6-Methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylates.

C. O. Kappe, U. G. Wagner,

Heterocycles, 1989, 29, 761-769.

2. Synthesis and Reactions of Biginelli Compounds, 1.

C. O. Kappe, P. Roschger,

J. Heterocycl. Chem., 1989, 26, 55-64. 

1. A Convenient Synthesis of Functionalized 1H-Pyrimidine-2-thiones.

Y. Akcamur, B. Altural, E. Saripinar, G. Kollenz, C. O. Kappe, K. Peters, E.-M. Peters, H.-G. von Schnering,

J. Heterocycl. Chem., 1988, 25, 1419-1422.