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Publikationen

2022

Danielczak B, Rasche M, Lenz J, Pérez Patallo E, Weyrauch S, Mahler F, Agbadaola MT, Meister A, Babalola JO, Vargas C, Kolar C, Keller S. A bioinspired glycopolymer for capturing membrane proteins in native-like lipid-bilayer nanodiscs. Nanoscale 2022, 5, 1855. PMID: 35040850

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2021

Schumann R, Bischoff E, Klaus S, Möhring S, Flock J, Keller S, Remans K, Ganter M, Deponte M. Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum. Redox Biol. 2021, 48, 102177. PMID 34773836

Mahler F, Meister A, Vargas C, Durand G, Keller S. Self-assembly of protein-containing lipid-bilayer nanodiscs from small-molecule amphiphiles. Small 2021, 17, 2103603. PMID 34674382

Grousson E, Mahler F, Keller S, Contino-Pépin C, Durand G. Hybrid fluorocarbon–hydrocarbon surfactants: synthesis and colloidal characterization. J. Org. Chem. 2021, 86, 14672. PMID 34609857

Tomazic N, Overkamp KE, Wegner H, Gu B, Mahler F, Aras M, Keller S, Pierik AJ, Hofmann E, Frankenberg-Dinkel N. Exchange of a single amino acid residue in the cryptophyte phycobiliprotein lyase GtCPES expands its substrate specificity. Biochim. Biophys. Acta Bioenerg. 2021, 1862, 148493. PMID 34537203

Janson K, Zierath J, Kyrilis FL, Semchonok DA, Hamdi F, Skalidis I, Kopf AH, Das M, Kolar C, Rasche M, Vargas C, Keller S, Kastritis PL, Meister A. Solubilization of artificial mitochondrial membranes by amphiphilic copolymers of different charge. Biochim. Biophys. Acta Biomembr. 2021, 1863, 183725. PMID 34384757

Hoffmann M, Haselberger D, Hofmann T, Müller L, Janson K, Meister A, Das M, Vargas C, Keller S, Kastritis PL, Schmidt C, Hinderberger D. Nanoscale model system for the human myelin sheath. Biomacromolecules 2021, 22, 3901. PMID 34324309

Hoffmann M, Eisermann J, Schöffmann FA, Das M, Vargas C, Keller S, Hinderberger D. Influence of different polymer belts on lipid properties in nanodiscs characterized by CW EPR spectroscopy. Biochim. Biophys. Acta Biomembr. 2021, 1863, 183681. PMID 34186033

Velazquez-Campoy A, Claro B, Abian O, Höring J, Bourlon L, Claveria-Gimeno R, Ennifar E, England P, Chaires JB, Wu D, Piszczek G, Brautigam C, Tso SC, Zhao H, Schuck P, Keller S, Bastos M. A multi-laboratory benchmark study of isothermal titration calorimetry (ITC) using Ca2+ and Mg2+ binding to EDTA. Eur. Biophys. J. 2021, 50, 4291. PMID 33864101

Wehbie M, Onyia KK, Mahler F, Le Roy A, Deletraz A, Bouchemal I, Vargas C, Babalola JO, Breyton C, Ebel C, Keller S, Durand G. Maltose-based fluorinated surfactants for membrane-protein extraction and stabilization. Langmuir 2021, 37, 2111. PMID 33539092

Eisermann J, Hoffmann M, Schöffmann FA, Das M, Vargas C, Keller S, Hinderberger D. Molecular-level interactions of nanodisc-forming copolymers dissected by EPR spectroscopy. Macromol. Chem. Phys. 2021, 222, 2100051.

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2020

Das M, Mahler F, Hariharan P, Wang H, Du Y, Mortensen JS, Patallo EP, Ghani L, Glück D, Lee HJ, Byrne B, Loland CJ, Guan L, Kobilka BK, Keller S, Chae PS. Diastereomeric cyclopentane-based maltosides (CPMs) as tools for membrane protein study. J. Am. Chem. Soc. 2020, 142, 21382. PMID 33315387

Danielczak B, Keller S. Lipid exchange among polymer-encapsulated nanodiscs by time-resolved Förster resonance energy transfer. Methods 2020, 180, 27. PMID 32371238

Adão R, Cruz PF, Vaz DC, Fonseca F, Pedersen JN, Ferreira-da-Silva F, Brito RMM, Ramos CHI, Otzen D, Keller S, Bastos M. DIBMA nanodiscs keep α-synuclein folded. Biochim. Biophys. Acta Biomembr. 2020, 1862, 183314. PMID 32304757

Tso SC, Mahler F, Höring J, Keller S, Brautigam CA. Fast and robust quantification of detergent micellization thermodynamics from isothermal titration calorimetry. Anal. Chem. 2020, 92, 1154. PMID 31829010

Bonnet C, Guillet P, Mahler F, Igonet S, Keller S, Jawhari A, Durand G. Detergent-like polymerizable monomers: synthesis, physicochemical, and biochemical characterization. Eur. J. Org. Chem. 2020, 33, 5340.

Nickolaus C, Vargas C, Reichenwallner J, Chakour M, Selmke B, Chakraborty R, Varadarajan R, Keller S, Trommer WE. The molten globule state of maltose-binding protein: structural and thermodynamic characterization by EPR spectroscopy and isothermal titration calorimetry. Appl. Magn. Reson. 2020, 51, 877.

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2019

Bonnet C, Guillet P, Igonet S, Meister A, Marconnet A, Keller S, Jawhari A, Durand G. Hybrid double-chain maltose-based detergents: synthesis and colloidal and biochemical evaluation. J. Org. Chem. 2019, 84, 10606. PMID 31414599

Krainer G, Keller S, Schlierf M. Structural dynamics of membrane-protein folding from single-molecule FRET. Curr. Opin. Struct. Biol. 2019, 58, 124. PMID 31323499

Ehsan M, Du Y, Mortensen JS, Hariharan P, Qu Q, Ghani L, Das M, Grethen A, Byrne B, Skiniotis G, Keller S, Loland CJ, Guan L, Kobilka BK, Chae PS. Self-assembly behavior and application of terphenyl-cored trimaltosides for membrane-protein studies: impact of detergent hydrophobic group geometry on protein stability. Chem. Eur. J. 2019, 25, 11545. PMID 31243822

Theis J, Gupta TK, Klingler J, Wan W, Albert S, Keller S, Engel BD, Schroda M. VIPP1 rods engulf membranes containing phosphatidylinositol phosphates. Sci. Rep. 2019, 9, 8725. PMID 31217458

August A, Schmidt N, Klingler J, Baumkötter F, Lechner M, Klement J, Eggert S, Vargas C, Wild K, Keller S, Kins S. Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways. J. Neurochem. 2019, 151, 626. PMID 31063592

Danielczak B, Meister A, Keller S. Influence of Mg2+ and Ca2+ on nanodisc formation by diisobutylene/maleic acid (DIBMA) copolymer. Chem. Phys. Lipids 2019, 221, 30. PMID 30876867

Guillet P, Mahler F, Garnier K, Boussambe GNM, Igonet S, Vargas C, Ebel C, Soulié M, Keller S, Jawhari A, Durand G. Hydrogenated diglucose detergents for membrane-protein extraction and stabilization. Langmuir 2019, 35, 4287. PMID 30767533

Rohr M, Ries F, Herkt C, Gotsmann VL, Westrich LD, Gries K, Trösch R, Christmann J, Chaux-Jukic F, Jung M, Zimmer D, Mühlhaus T, Sommer F, Schroda M, Keller S, Möhlmann T, Willmund F. The role of plastidic trigger factor serving protein biogenesis in green algae and land plants. Plant Physiol. 2019, 179, 1093. PMID 30651302

Höfer CT, Di Lella S, Dahmani I, Jungnick N, Bordag N, Bobone S, Huang Q, Keller S, Herrmann A, Chiantia S. Structural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes. Biochim. Biophys. Acta Biomembr. 2019, 1861, 1123. PMID 30902626

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2018

Frotscher E, Krainer G, Schlierf M, Keller S. Dissecting nanosecond dynamics in membrane proteins with dipolar relaxation upon tryptophan photoexcitation. J. Phys. Chem. Lett. 2018, 9, 2241. PMID 29652505

Karim A, Schulz N, Andersson H, Nekoueishahraki B, Carlsson AC, Sarabi D, Valkonen A, Rissanen K, Gräfenstein J, Keller S, Erdélyi M. Carbon's three-center, four-electron tetrel bond, treated experimentally. J. Am. Chem. Soc. 2018, 140, 17571. PMID 30484646

Krainer G, Treff A, Hartmann A, Stone TA, Schenkel M, Keller S, Deber CM, Schlierf M. A minimal helical-hairpin motif provides molecular-level insights into misfolding and pharmacological rescue of CFTR. Commun. Biol. 2018, 1, 154. PMID 30302398

Atkovska K, Klingler J, Oberwinkler J, Keller S, Hub JS. Rationalizing steroid interactions with lipid membranes: conformations, partitioning, and kinetics. ACS Cent. Sci. 2018, 4, 1155. PMID 30276248

Rao BD, Chakraborty H, Keller S, Chattopadhyay A. Aggregation behavior of pHLIP in aqueous solution at low concentrations: a fluorescence study. J. Fluoresc. 2018, 28, 967. PMID 29959578

Bondar AN, Keller S. Lipid membranes and reactions at lipid interfaces: theory, experiments, and applications. J. Membr. Biol. 2018, 251, 295. PMID 29959445

Boussambe GNM, Guillet P, Mahler F, Marconnet A, Vargas C, Cornut D, Soulié M, Ebel C, Le Roy A, Jawhari A, Bonneté F, Keller S, Durand G. Fluorinated diglucose detergents for membrane-protein extraction. Methods 2018, 147, 84. PMID 29857192

Vargas C, Schönbeck C, Heimann I, Keller S. Extracavity effect in cyclodextrin/surfactant complexation. Langmuir 2018, 34, 5781. PMID 29683671

Frotscher E, Krainer G, Hartmann A, Schlierf M, Keller S. Conformational dynamics govern the free-energy landscape of a membrane-interacting protein. ACS Omega 2018, 3, 12026. PMID 31459283

Grethen A, Glueck D, Keller S. Role of Coulombic repulsion in collisional lipid transfer among SMA(2:1)-bounded nanodiscs. J. Membr. Biol. 2018, 251, 443. PMID 29508005

Krainer G, Hartmann A, Anandamurugan A, Gracia P, Keller S, Schlierf M. Ultrafast protein folding in membrane-mimetic environments. J. Mol. Biol. 2018, 430, 554. PMID 29128595

Danielczak B, Keller S. Collisional lipid exchange among DIBMA-encapsulated nanodiscs (DIBMALPs). Eur. Polym. J. 2018, 109, 206.

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2017

Oluwole AO, Klingler J, Danielczak B, Babalola JO, Vargas C, Pabst G, Keller S. Formation of lipid-bilayer nanodiscs by diisobutylene/maleic acid (DIBMA) copolymer. Langmuir 2017, 33, 14378. PMID 29160078

Grethen A, Oluwole AO, Danielczak B, Vargas C, Keller S. Thermodynamics of nanodisc formation mediated by styrene/maleic acid (2:1) copolymer. Sci. Rep. 2017, 7, 11517. PMID 28912575

Ries F, Carius Y, Rohr M, Gries K, Keller S, Lancaster CRD, Willmund F. Structural and molecular comparison of bacterial and eukaryotic trigger factors. Sci. Rep. 2017, 7, 10680. PMID 28878399

Krainer G, Gracia P, Frotscher E, Hartmann A, Gröger P, Keller S, Schlierf M. Slow interconversion in a heterogeneous unfolded-state ensemble of outer-membrane phospholipase A. Biophys. J. 2017, 113, 1280. PMID 28629619

Cuevas Arenas R, Danielczak B, Martel A, Porcar L, Breyton C, Ebel C, Keller S. Fast collisional lipid transfer among polymer-bounded nanodiscs. Sci. Rep. 2017, 7, 45875. PMID 28378790

Rangl M, Rima L, Klement J, Miyagi A, Keller S, Scheuring S. Real-time visualization of phospholipid degradation by outer membrane phospholipase A using high-speed atomic force microscopy. J. Mol. Biol. 2017, 429, 977. PMID 28283404

Frotscher E, Höring J, Durand G, Vargas C, Keller S. Model-free analysis of critical micellar concentrations for detecting demixing in surfactant mixtures. Anal. Chem. 2017, 89, 3245. PMID 28267311

Oluwole AO, Danielczak B, Meister A, Babalola JO, Vargas C, Keller S. Solubilization of membrane proteins into functional lipid-bilayer nanodiscs using a diisobutylene/maleic acid copolymer. Angew. Chem. Int. Ed. 2017, 56, 1919. PMID 28079955

Mungalpara D, Kelm H, Valkonen A, Keller S, Kubik S. Oxoanion binding to a cyclic pseudopeptide containing 1,4-disubstituted 1,2,3-triazole moieties. Org. Biomol. Chem. 2017, 15, 102. PMID 27805227

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2016

Cuevas Arenas R, Klingler J, Vargas C, Keller S. Influence of lipid bilayer properties on nanodisc formation mediated by styrene/maleic acid copolymers. Nanoscale 2016, 8, 15016. PMID 27471007

Keller S, Bondar AN, Broecker J, Ladokhin AS, Sinner EK. Journal of Membrane Biology: Biophysics. J. Membr. Biol. 2016, 249, 5. PMID 27097636

Brautigam CA, Zhao H, Vargas C, Keller S, Schuck P. Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions. Nat. Protoc. 2016, 11, 882. PMID 27055097

Panigrahi R, Arutyunova E, Panwar P, Gimpl K, Keller S, Lemieux MJ. Reversible unfolding of rhomboid intramembrane proteases. Biophys. J. 2016, 110, 1379. PMID 27028647

Gimpl K, Klement J, Keller S. Characterising protein/detergent complexes by triple-detection size-exclusion chromatography. Biol. Proced. Online 2016, 18, 4. PMID 26880869

Textor M, Keller S. Calorimetric quantification of cyclodextrin-mediated detergent extraction for membrane-protein reconstitution. Methods Enzymol. 2016, 567, 129. PMID 26794353

Polidori A, Raynal S, Barret LA, Dahani M, Barrot-Ivolot C, Jungas C, Frotscher E, Keller S, Ebel C, Breyton C, Bonneté F. Sparingly fluorinated maltoside-based surfactants for membrane-protein stabilization. New J. Chem. 2016, 40, 5364.

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2015

Vargas C, Cuevas Arenas R, Frotscher E, Keller S. Nanoparticle self-assembly in mixtures of phospholipids with styrene/maleic acid copolymers or fluorinated surfactants. Nanoscale 2015, 7, 20685. PMID 26599076

Hartmann A, Krainer G, Keller S, Schlierf M. Quantification of millisecond protein-folding dynamics in membrane-mimetic environments by single-molecule FRET spectroscopy. Anal. Chem. 2015, 87, 11224. PMID 26457727

Jungbauer SH, Schindler S, Herdtweck E, Keller S, Huber SM. Multiple multidentate halogen bonding in solution, in the solid state, and in the (calculated) gas phase. Chem. Eur. J. 2015, 21, 13625. PMID 26331633

Scheidt HA, Klingler J, Huster D, Keller S. Structural thermodynamics of myr‑Src(2–19) binding to phospholipid membranes. Biophys. J. 2015, 109, 586. PMID 26244740

Textor M, Keller S. Automated analysis of calorimetric demicellization titrations. Anal. Biochem. 2015, 485, 119. PMID 26079704

Herrmann M, Danielczak B, Textor M, Klement J, Keller S. Modulating bilayer mechanical properties to promote the coupled folding and insertion of an integral membrane protein. Eur. Biophys. J. 2015, 44, 503. PMID 26016666

Chaires JB, Hansen LD, Keller S, Brautigam CA, Zhao H, Schuck P. Biocalorimetry. Methods 2015, 76, 1. PMID 25817327

Frotscher E, Danielczak B, Vargas C, Meister A, Durand G, Keller S. A fluorinated detergent for membrane-protein applications. Angew. Chem. Int. Ed. 2015, 54, 5069. PMID 25753129

Klingler J, Vargas C, Fiedler S, Keller S. Preparation of ready-to-use small unilamellar phospholipid vesicles by ultrasonication with a beaker resonator. Anal. Biochem. 2015, 477, 10. PMID 25712041

Abla M, Unger S, Keller S, Bonneté F, Ebel C, Pucci B, Breyton C, Durand G. Micellar and biochemical properties of a propyl-ended fluorinated surfactant designed for membrane-protein study. J. Colloid Interface Sci. 2015, 445, 127. PMID 25616252

Textor M, Vargas C, Keller S. Calorimetric quantification of linked equilibria in cyclodextrin/lipid/detergent mixtures for membrane-protein reconstitution. Methods 2015, 76, 183. PMID 25583305

Krainer G, Keller S. Single-experiment displacement assay for quantifying high-affinity binding by isothermal titration calorimetry. Methods 2015, 76, 116. PMID 25461813

Marino J, Bordag N, Keller S, Zerbe O. Mistic's membrane association and its assistance in overexpression of a human GPCR are independent processes. Protein Sci. 2015, 24, 38. PMID 25297828

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2014

Stangl M, Unger S, Keller S, Schneider D. Sequence-specific dimerization of a transmembrane helix in Amphipol A8‑35. PLoS One 2014, 9, e110970. PMID 25347769

Bogomolova A, Keller S, Klingler J, Sedlak M, Rak D, Sturcova A, Hruby M, Stepanek P, Filippov SK. Self-assembly thermodynamics of pH-responsive amino-acid-based polymers with a nonionic surfactant. Langmuir 2014, 30, 11307. PMID 25192406

Broecker J, Fiedler S, Gimpl K, Keller S. Polar interactions trump hydrophobicity in stabilizing the self-inserting membrane protein Mistic. J. Am. Chem. Soc. 2014, 136, 13761. PMID 25177765

Baumkötter F, Schmidt N, Vargas C, Schilling S, Weber R, Wagner K, Fiedler S, Klug W, Radzimanowski J, Nickolaus S, Keller S, Eggert S, Wild K, Kins S. Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain. J. Neurosci. 2014, 34, 11159. PMID 25122912

Kükenshöner T, Hagemann UB, Wohlwend D, Räuber C, Baumann T, Keller S, Einsle O, Müller KM, Arndt KM. Analysis of selected and designed chimeric D- and L‑α-helix assemblies. Biomacromolecules 2014, 15, 3296. PMID 25072521

Vargas C, Radziwill G, Krause G, Diehl A, Keller S, Kamdem N, Czekelius C, Kreuchwig A, Schmieder P, Doyle D, Moelling K, Hagen V, Schade M, Oschkinat H. Small-molecule inhibitors of AF6 PDZ-mediated protein–protein interactions. ChemMedChem 2014, 9, 1458. PMID 24668962

Abraham T, Prenner EJ, Lewis RN, Mant CT, Keller S, Hodges RS, McElhaney RN. Structure–activity relationships of the antimicrobial peptide gramicidin S and its analogs: aqueous solubility, self-association, conformation, antimicrobial activity and interaction with model lipid membranes. Biochim. Biophys. Acta Biomembr. 2014, 1838, 1420. PMID 24388950

Jahnke N, Krylova OO, Hoomann T, Vargas C, Fiedler S, Pohl P, Keller S. Real-time monitoring of membrane-protein reconstitution by isothermal titration calorimetry. Anal. Chem. 2014, 86, 920. PMID 24354292

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2013

Heerklotz H, Keller S. How membrane partitioning modulates receptor activation: parallel versus serial effects of hydrophobic ligands. Biophys. J. 2013, 105, 2607. PMID 24359728

Jacso T, Bardiaux B, Broecker J, Fiedler S, Baerwinkel T, Mainz A, Fink U, Vargas C, Oschkinat H, Keller S, Reif B. The mechanism of denaturation and the unfolded state of the α-helical membrane-associated protein Mistic. J. Am. Chem. Soc. 2013, 135, 18884. PMID 24261476

Vocke K, Dauner K, Hahn A, Ulbrich A, Broecker J, Keller S, Frings S, Möhrlen F. Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels. J. Gen. Physiol. 2013, 142, 381. PMID 24081981

Vargas C, Klingler J, Keller S. Membrane partitioning and translocation studied by isothermal titration calorimetry. Methods Mol. Biol. 2013, 1033, 253. PMID 23996182

Hoomann T, Jahnke N, Horner A, Keller S, Pohl P. Filter gate closure inhibits ion but not water transport through potassium channels. Proc. Natl. Acad. Sci. USA 2013, 110, 10842. PMID 23754382

Broecker J, Keller S. Impact of urea on detergent micelle properties. Langmuir 2013, 29, 8502. PMID 23745835

Fiedler S, Cole L, Keller S. Automated circular dichroism spectroscopy for medium-throughput analysis of protein conformation. Anal. Chem. 2013, 85, 1868. PMID 23252393

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2012

Krainer G, Broecker J, Vargas C, Fanghänel J, Keller S. Quantifying high-affinity binding of hydrophobic ligands by isothermal titration calorimetry. Anal. Chem. 2012, 84, 10715. PMID 23130786

Schaal J, Dekowski B, Wiesner B, Eichhorst J, Marter K, Vargas C, Keller S, Eremina N, Barth A, Baumann A, Eisenhardt D, Hagen V. Coumarin-based octopamine phototriggers and their effects on an insect octopamine receptor. ChemBioChem 2012, 13, 1458. PMID 22674503

Keller S, Vargas C, Zhao H, Piszczek G, Brautigam CA, Schuck P. High-precision isothermal titration calorimetry with automated peak-shape analysis. Anal. Chem. 2012, 84, 5066. PMID 22530732

Islam MR, Nishie M, Nagao J, Keller S, Nakayama J, Kohda D, Sahl HG, Sonomoto K. Ring A of nukacin ISK-1: a lipid II-binding motif for type–A(II) lantibiotic. J. Am. Chem. Soc. 2012, 134, 3687. PMID 22329487

Lossie J, Ushakov DS, Ferenczi MA, Werner S, Keller S, Haase H, Morano I. Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting. Cardiovasc. Res. 2012, 93, 390. PMID 22131351

Jacso T, Franks WT, Rose H, Fink U, Broecker J, Keller S, Oschkinat H, Reif B. Characterization of membrane proteins in isolated native cellular membranes by dynamic nuclear polarization solid-state NMR spectroscopy without purification and reconstitution. Angew. Chem. Int. Ed. 2012, 51, 4325. PMID 22113890

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2011

Klöppel C, Suzuki Y, Kojer K, Petrungaro C, Longen S, Fiedler S, Keller S, Riemer J. Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol. Mol. Biol. Cell 2011, 22, 3749. PMID 21865594

Broecker J, Vargas C, Keller S. Revisiting the optimal c value for isothermal titration calorimetry. Anal. Biochem. 2011, 418, 307. PMID 21854755

Ungerer N, Mücke N, Broecker J, Keller S, Frings S, Möhrlen F. Distinct binding properties distinguish LQ-type calmodulin-binding domains in cyclic nucleotide-gated channels. Biochemistry 2011, 50, 3221. PMID 21413724

Petzhold D, Lossie J, Keller S, Werner S, Haase H, Morano I. Human essential myosin light chain isoforms revealed distinct myosin binding, sarcomeric sorting, and inotropic activity. Cardiovasc. Res. 2011, 90, 513. PMID 21262909

Siegert R, Perrot A, Keller S, Behlke J, Michalewska-Włudarczyk A, Wycisk A, Tendera M, Morano I, Ozcelik C. A myomesin mutation associated with hypertrophic cardiomyopathy deteriorates dimerisation properties. Biochem. Biophys. Res. Commun. 2011, 405, 473. PMID 21256114

Bagheri M, Keller S, Dathe M. Interaction of W‑substituted analogs of cyclo-RRRWFW with bacterial lipopolysaccharides: the role of the aromatic cluster in antimicrobial activity. Antimicrob. Agents Chemother. 2011, 55, 788. PMID 21098244

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2010

Hilpert K, McLeod B, Yu J, Elliott MR, Rautenbach M, Ruden S, Bürck J, Muhle-Goll C, Ulrich AS, Keller S, Hancock RE. Short cationic antimicrobial peptides interact with ATP. Antimicrob. Agents Chemother. 2010, 54, 4480. PMID 20660668

Petzhold D, Lossie J, Behlke J, Keller S, Haase H, Morano I. Auto-inhibitory effects of an IQ motif on protein structure and function. Biochem. Biophys. Res. Commun. 2010, 396, 939. PMID 20460111

Krylova OO, Jahnke N, Keller S. Membrane solubilisation and reconstitution by octylglucoside: comparison of synthetic lipid and natural lipid extract by isothermal titration calorimetry. Biophys. Chem. 2010, 150, 105. PMID 20392557

Kemmer G, Keller S. Nonlinear least-squares data fitting in Excel spreadsheets. Nat. Protoc. 2010, 5, 267. PMID 20134427

Vahedi-Faridi A, Licht A, Bulut H, Scheffel F, Keller S, Wehmeier UF, Saenger W, Schneider E. Crystal structures of the solute receptor GacH of Streptomyces glaucescens in complex with acarbose and an acarbose homolog: comparison with the acarbose-loaded maltose-binding protein of Salmonella typhimurium. J. Mol. Biol. 2010, 397, 709. PMID 20132828

Fiedler S, Broecker J, Keller S. Protein folding in membranes. Cell. Mol. Life Sci. 2010, 67, 1779. PMID 20101433

Broecker J, Keller S. Membrane translocation assayed by fluorescence spectroscopy. Methods Mol. Biol. 2010, 606, 271. PMID 20013403

Kahlfeldt N, Vahedi-Faridi A, Koo SJ, Schäfer JG, Krainer G, Keller S, Saenger W, Krauss M, Haucke V. Molecular basis for association of PIPKIγ-p90 with clathrin adaptor AP-2. J. Biol. Chem. 2010, 285, 2734. PMID 19903820

Bordag N, Keller S. α-helical transmembrane peptides: a "divide and conquer" approach to membrane proteins. Chem. Phys. Lipids 2010, 163, 1. PMID 19682979

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2009

Schmidt MF, El-Dahshan A, Keller S, Rademann J. Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase‑3 inhibitor. Angew. Chem. Int. Ed. 2009, 48, 6346. PMID 19630042

Schlundt A, Sticht J, Piotukh K, Kosslik D, Jahnke N, Keller S, Schuemann M, Krause E, Freund C. Proline-rich sequence recognition II: proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions. Mol. Cell. Proteomics 2009, 8, 2474. PMID 19542561

Heerklotz H, Tsamaloukas AD, Keller S. Monitoring detergent-mediated solubilization and reconstitution of lipid membranes by isothermal titration calorimetry. Nat. Protoc. 2009, 4, 686. PMID 19373233

Jacso T, Grote M, Daus ML, Schmieder P, Keller S, Schneider E, Reif B. Periplasmic loop P2 of the MalE subunit of the maltose ATP binding cassette transporter is sufficient to bind the maltose binding protein MalE. Biochemistry 2009, 48, 2216. PMID 19159328

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2007

Tsamaloukas A, Keller S, Heerklotz H. Uptake and release protocol for assessing membrane binding and permeation by way of isothermal titration calorimetry. Nat. Protoc. 2007, 2, 695. PMID 17406632

Keller S, Böthe M, Bienert M, Dathe M, Blume A. A simple fluorescence-spectroscopic membrane translocation assay. ChemBioChem 2007, 8, 546. PMID 17330902

Portwich M, Keller S, Strauss HM, Mahrenholz CC, Kramer A, Kretzschmar I, Volkmer R. A network of coiled-coil associations derived from synthetic GCN4 leucine zipper arrays. Angew. Chem. Int. Ed. 2007, 46, 1654. PMID 17211913

Gilbert D, Funk K, Lechler R, Keller S, Möhrlen F, Frings S, Hagen V. Caged capsaicins: new tools for the examination of TRPV1 channels in somatosensory neurons. ChemBioChem 2007, 8, 89. PMID 17154194

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2006

Sauer I, Nikolenko H, Keller S, Abu Ajaj K, Bienert M, Dathe M. Dipalmitoylation of a cellular uptake-mediating apolipoprotein E-derived peptide as a promising modification for stable anchorage in liposomal drug carriers. Biochim. Biophys. Acta Biomembr. 2006, 1758, 552. PMID 16681993

Keller S, Heerklotz H, Jahnke N, Blume A. Thermodynamics of lipid membrane solubilization by sodium dodecyl sulfate. Biophys. J. 2006, 90, 4509. PMID 16581838

Cambridge SB, Geissler D, Keller S, Cürten B. A caged doxycycline analogue for photoactivated gene expression. Angew. Chem. Int. Ed. 2006, 45, 2229. PMID 16506298

Keller S, Heerklotz H, Blume A. Monitoring lipid membrane translocation of sodium dodecyl sulfate by isothermal titration calorimetry. J. Am. Chem. Soc. 2006, 128, 1279. PMID 16433546

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2005

Hagen V, Dekowski B, Nache V, Schmidt R, Geissler D, Lorenz D, Eichhorst J, Keller S, Kaneko H, Benndorf K, Wiesner B. Coumarinylmethyl esters for ultrafast release of high concentrations of cyclic nucleotides upon one- and two-photon photolysis. Angew. Chem. Int. Ed. 2005, 44, 7887. PMID 16270373

Keller S, Tsamaloukas A, Heerklotz H. A quantitative model describing the selective solubilization of membrane domains. J. Am. Chem. Soc. 2005, 127, 11469. PMID 16089477

Bárány-Wallje E, Keller S, Serowy S, Geibel S, Pohl P, Bienert M, Dathe M. A critical reassessment of penetratin translocation across lipid membranes. Biophys. J. 2005, 89, 2513. PMID 16040762

Keller S, Sauer I, Strauss H, Gast K, Dathe M, Bienert M. Membrane-mimetic nanocarriers formed by a dipalmitoylated cell-penetrating peptide. Angew. Chem. Int. Ed. 2005, 44, 5252. PMID 16035010

Geissler D, Antonenko YN, Schmidt R, Keller S, Krylova OO, Wiesner B, Bendig J, Pohl P, Hagen V. (Coumarin-4‑yl)-methyl esters as highly efficient, ultrafast phototriggers for protons and their application to acidifying membrane surfaces. Angew. Chem. Int. Ed. 2005, 44, 1195. PMID 15696594

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Buchkapitel

Höring J, Keller S. Gibbs energies in biomolecular solutions. In Gibbs Energy and Helmholtz Energy: Liquids, Solutions and Vapours; Wilhelm E, Letcher T, Eds.; The Royal Society of Chemistry: London, 2021, 299.

Paketurytė V, Zubrienė A, Chen WY, Keller S, Bastos M, Todd MJ, Ladbury JE, Matulis D. Inhibitor binding to carbonic anhydrases by isothermal titration calorimetry. In Carbonic Anhydrase as Drug Target; Matulis D, Ed.; Springer Nature: Cham, 2019, 79.

Klingler J, Keller S. Peptide–membrane interactions studied by isothermal titration calorimetry. In Biocalorimetry: Foundations and Contemporary Approaches; Bastos M, Ed.; CRC Press: Boca Raton, 2016, 153.

Strauss HM, Keller S. Pharmacological interference with protein–protein interactions mediated by coiled-coil motifs. In Protein–Protein Interactions as New Drug Targets; Klussmann E, Scott J, Eds.; Springer-Verlag: Berlin, 2008, 461. PMID 18491064

Dathe M, Keller S, Sauer I, Bienert M. Cellular uptake of liposomal and micellar carriers mediated by apoE-derived peptides. In Handbook of Cell-Penetrating Peptides; Langel Ü, Ed.; CRC Press: Boca Raton, 2006, 483.

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Univ.-Prof. Dr.

Sandro Keller

Institut für Molekulare Biowissenschaften (IMB)
Humboldtstr. 50/III
8010 Graz

Telefon:+43 (0)316 380 - +43 316 380 - 4987

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